{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:55:11Z","timestamp":1791431711761,"version":"4.3.3"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/7\/509\/10\u2010RHN"],"award-info":[{"award-number":["5\/7\/509\/10\u2010RHN"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n To determine the value of placenta growth factor (Pl\n GF<\/jats:styled-content>\n ) for predicting hypertensive disorders of pregnancy (\n HDP<\/jats:styled-content>\n ) in a low\u2010risk population when used either alone or in combination with other markers.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A prospective observational cohort study was conducted among women with singleton pregnancy in the first trimester in New Delhi, India, between October 1, 2013, and September 30, 2016. First\u2010trimester measures included maternal history, body mass index (\n BMI<\/jats:styled-content>\n ), mean arterial pressure (\n MAP<\/jats:styled-content>\n ), Doppler uterine artery pulsatility index, and serum levels of biomarkers (including Pl\n GF<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 1725 women, 208 (12.1%) developed\n HDP<\/jats:styled-content>\n ; 74 (35.6%) of these cases were early onset. Mean Pl\n GF<\/jats:styled-content>\n levels were significantly lower among cases than among controls (30.42\u00a0\u00b1\u00a010.22 vs 37.31\u00a0\u00b1\u00a013.28\u00a0pg\/\n mL<\/jats:styled-content>\n ;\n P<<\/jats:italic>\n 0.001). As a biomarker for prediction of\n HDP<\/jats:styled-content>\n , Pl\n GF<\/jats:styled-content>\n fared better than pregnancy\u2010associated plasma protein A (\n PAPP<\/jats:styled-content>\n \u2010A): area under the curve 0.685 (95% confidence interval [\n CI<\/jats:styled-content>\n ] 0.620\u20130.750;\n P<<\/jats:italic>\n 0.001) versus 0.659 (95%\n CI<\/jats:styled-content>\n 0.593\u20130.726;\n P<<\/jats:italic>\n 0.001). The highest odds ratio was found for\n MAP<\/jats:styled-content>\n (8.369, 95%\n CI<\/jats:styled-content>\n 5.752\u201312.215). The combination of Pl\n GF<\/jats:styled-content>\n ,\n PAPP<\/jats:styled-content>\n \u2010A,\n BMI<\/jats:styled-content>\n ,\n MAP<\/jats:styled-content>\n , and Doppler uterine artery pulsatility index provided an area under the receiver operating characteristic curve of 0.876 (95%\n CI<\/jats:styled-content>\n 0.833\u20130.919;\n P<<\/jats:italic>\n 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Combining Pl\n GF<\/jats:styled-content>\n concentration with biochemical and biophysical markers provided a good screening test for\n HDP<\/jats:styled-content>\n during the first trimester.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.12301","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T04:23:40Z","timestamp":1502943820000},"page":"301-306","source":"Crossref","is-referenced-by-count":9,"title":["Use of first\u2010trimester placenta growth factor concentration to predict hypertensive disorders of pregnancy in a low\u2010risk Asian population"],"prefix":"10.1002","volume":"139","author":[{"given":"Manisha","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karuna","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Reproductive Biology Maternal and Child Health Indian Council of Medical Research New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abha","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayashree","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,13]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"ACOG task force on Hypertension in pregnancy.https:\/\/www.acog.org\/~\/media\/Task%20Force%20and%20Work%20Group%20Reports\/public\/HypertensioninPregnancy.pdf. 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