{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:55:11Z","timestamp":1791431711794,"version":"4.3.3"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T00:00:00Z","timestamp":1506038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T00:00:00Z","timestamp":1506038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the fetal brain in pregnant women infected with Zika virus in a limited\u2010resource setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In an observational study in Trinidad and Tobago, 100 pregnant women infected with Zika virus who were referred for fetal medicine services provided by a single clinician were enrolled from March 31 to September 2, 2016. Two\u2010dimensional ultrasonography was undertaken.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The women were aged 17\u201341\u00a0years (mean 27.5\u00a0\u00b1\u00a05.7). Six cases of fetal brain abnormalities consistent with Zika infection were detected before 26 gestational weeks. The gestational period at infection and time of presentation ranged, respectively, from 7\n                      <jats:sup>+3<\/jats:sup>\n                      to 16\n                      <jats:sup>+0<\/jats:sup>\n                      \u00a0weeks and from 23\n                      <jats:sup>+2<\/jats:sup>\n                      to 25\n                      <jats:sup>+5<\/jats:sup>\n                      \u00a0weeks. In all cases, centiles of the biparietal diameter and head circumference decreased progressively over time to below the third centile. The skull contour appeared irregular, owing to collapse or overlap of the fetal skull bones. In four cases, brain anomalies were not obvious on the transabdominal scan but were diagnosed on the transvaginal scan. In a further two cases, brain abnormalities presented after 26\u00a0weeks of gestation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, 8.0% of women infected with Zika virus had fetuses with brain abnormalities suggestive of Zika congenital syndrome. Six cases were detected before 26\u00a0weeks and two cases after 26\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.12313","type":"journal-article","created":{"date-parts":[[2017,8,26]],"date-time":"2017-08-26T05:46:38Z","timestamp":1503726398000},"page":"278-283","source":"Crossref","is-referenced-by-count":11,"title":["Ultrasonographic observations of the fetal brain in the first 100 pregnant women with Zika virus infection in Trinidad and Tobago"],"prefix":"10.1002","volume":"139","author":[{"given":"Karen","family":"Sohan","sequence":"first","affiliation":[{"name":"Zika Antenatal Screening Program  Champ Fleurs Trinidad and Tobago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy A.","family":"Cyrus","sequence":"additional","affiliation":[{"name":"Zika Antenatal Screening Program  Champ Fleurs Trinidad and Tobago"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,22]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Index Mundi.Trinidad and Tobago.http:\/\/www.indexmundi.com\/trinidad_and_tobago\/. Accessed August 25 2017."},{"key":"e_1_2_8_3_1","unstructured":"Ministry of Health Trinidad and Tobago.Zika being treated as a public health emergency.http:\/\/www.health.gov.tt\/news\/newsitem.aspx?id=623. Published January 29 2016. Accessed May 29 2017."},{"key":"e_1_2_8_4_1","unstructured":"Ministry of Health Trinidad and Tobago.The Ministry of Health confirms its first Zika case.http:\/\/www.health.gov.tt\/news\/newsitem.aspx?id=630. Published February 17 2016. Accessed May 29 2017."},{"key":"e_1_2_8_5_1","unstructured":"Ministry of Health Trinidad and Tobago.Management of Zika positive pregnant patients.http:\/\/www.health.gov.tt\/news\/newsitem.aspx?id=732. Published February 23 2017. Accessed May 29 2017."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1604338"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtm.2016.05.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6549e1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30270-5"},{"key":"e_1_2_8_10_1","unstructured":"Centers for Disease Control and Prevention.Guidelines for the Management of Zika Virus.http:\/\/www.cdc.gov\/zika\/. Accessed August 19 2017."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15896"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13429"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3909"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016161584"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15831"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13007.x"},{"key":"e_1_2_8_17_1","unstructured":"Better World Campaign.The UN's role in combating the Zika virus.https:\/\/betterworldcampaign.org\/un-101\/current-issues\/who-zika-virus\/. Published 2016. 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