{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:55:02Z","timestamp":1791431702765,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n To study the correlation between M2 tumor\u2010associated macrophages (\n TAM<\/jats:styled-content>\n s) and invasion patterns in cervical squamous cell carcinoma (\n SCC<\/jats:styled-content>\n ) tissues.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In the present observational study, two commercial\n SCC<\/jats:styled-content>\n tissue microarrays were evaluated by immunohistochemical analysis between January 1, 2016, and December 31, 2016.\n CD<\/jats:styled-content>\n 163\u2010positive cells in a cervical\n SCC<\/jats:styled-content>\n tissue microarray were identified. Tissue samples were stratified into groups based on a pushing border pattern (\n PBP<\/jats:styled-content>\n ), a diffuse infiltration pattern (\n DIP<\/jats:styled-content>\n ), or non\u2010tumorous tissues included as a control group; M2\n TAM<\/jats:styled-content>\n numbers and distributions were compared.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The microarrays included 109 cervical\n SCC<\/jats:styled-content>\n samples and 45 non\u2010tumorous control samples. The mean number of intratumoral M2\n TAM<\/jats:styled-content>\n s in cervical\n SCC<\/jats:styled-content>\n tissue samples (35.8\u00a0\u00b1\u00a028.3) was significantly higher than the number of intraepithelial M2\n TAM<\/jats:styled-content>\n s in non\u2010tumorous cervical samples (1.2\u00a0\u00b1\u00a03.6) (\n P<<\/jats:italic>\n 0.001); similarly, the number of peritumoral M2\n TAM<\/jats:styled-content>\n s in cervical\n SCC<\/jats:styled-content>\n (44.7\u00a0\u00b1\u00a029.4) was higher than in non\u2010tumorous cervical tissues (10.4\u00a0\u00b1\u00a09.2) (\n P<<\/jats:italic>\n 0.001). The numbers of intratumoral (\n P=<\/jats:italic>\n 0.046) and peritumoral (\n P=<\/jats:italic>\n 0.002) M2\n TAM<\/jats:styled-content>\n s were higher among the\n DIP<\/jats:styled-content>\n group compared with the\n PBP<\/jats:styled-content>\n group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n A close relationship was identified between M2\n TAM<\/jats:styled-content>\n s and invasion patterns in cervical\n SCC<\/jats:styled-content>\n . Further, M2\n TAM<\/jats:styled-content>\n infiltration was more pronounced in\n DIP<\/jats:styled-content>\n compared with\n PBP SCC<\/jats:styled-content>\n tissue samples.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.12320","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T06:55:58Z","timestamp":1504853758000},"page":"346-351","source":"Crossref","is-referenced-by-count":17,"title":["Associations between intratumoral and peritumoral M2 macrophage counts and cervical squamous cell carcinoma invasion patterns"],"prefix":"10.1002","volume":"139","author":[{"given":"Yuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Linfen People's Hospital Linfen Shanxi China"},{"name":"Department of Obstetrics and Gynecology Ningxia Medical University Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaosheng","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology Department of Pathology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ningxia Medical University Yinchuan Ningxia China"},{"name":"Department of Gynecology The First Affiliated Hospital of Xi'an Medical College Xi'an Shaanxi 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