{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:53:26Z","timestamp":1764402806485},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["50274"],"award-info":[{"award-number":["50274"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To describe the effect of maternal vaccination on birth outcomes in rural Nepal, modified by timing of vaccination in pregnancy and influenza virus activity.<\/jats:p><\/jats:sec>Methods<\/jats:title>A secondary analysis was conducted using data from two annual cohorts of a randomized controlled trial. A total of 3693 pregnant women from Sarlahi District were enrolled between April 25, 2011, and September 9, 2013. All participants were aged 15\u201340\u00a0years and received a trivalent inactivated influenza vaccine or placebo. The outcome measures included birth weight, pregnancy length, low birth weight (<2500\u00a0g), preterm birth, and small\u2010for\u2010gestational\u2010age birth.<\/jats:p><\/jats:sec>Results<\/jats:title>Data were available on birth weight for 2741 births and on pregnancy length for 3623 births. Maternal vaccination increased mean birthweight by 42\u00a0g (95% confidence interval [CI<\/jats:styled-content>] 8\u201376). The magnitude of this increase varied by season but was greatest among pregnancies with high influenza virus circulation during the third trimester. Birth weight increased by 111\u00a0g (95% CI<\/jats:styled-content> \u221251 to 273) when 75%\u2013100% of a\u00a0pregnancy's third trimester had high influenza virus circulation versus 38\u00a0g (95% CI<\/jats:styled-content> \u22126 to 81) when 0%\u201325% of a pregnancy's third trimester had high influenza virus circulation. However, these results were nonsignificant.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Seasonal maternal influenza vaccination in rural Nepal increased birth weight; the magnitude appeared larger during periods of high influenza virus circulation.<\/jats:p><\/jats:sec>ClinicalTrials.gov<\/jats:title>NCT<\/jats:styled-content>01034254.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12341","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T13:36:41Z","timestamp":1507297001000},"page":"65-72","source":"Crossref","is-referenced-by-count":10,"title":["Impact of maternal vaccination timing and influenza virus circulation on birth outcomes in rural Nepal"],"prefix":"10.1002","volume":"140","author":[{"given":"Naoko","family":"Kozuki","sequence":"first","affiliation":[{"name":"Department of International Health Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of International Health Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet A.","family":"Englund","sequence":"additional","affiliation":[{"name":"Seattle Children's Hospital and Research Foundation University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark C.","family":"Steinhoff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subarna K.","family":"Khatry","sequence":"additional","affiliation":[{"name":"Nepal Nutrition Intervention Project \u2013 Sarlahi Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laxman","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Institute of Medicine Tribhuvan University Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Kuypers","sequence":"additional","affiliation":[{"name":"Molecular Virology Laboratory School of Medicine University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke C.","family":"Mullany","sequence":"additional","affiliation":[{"name":"Department of International Health Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen Y.","family":"Chu","sequence":"additional","affiliation":[{"name":"Harborview Medical Center University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C.","family":"LeClerq","sequence":"additional","affiliation":[{"name":"Department of International Health Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"},{"name":"Nepal Nutrition Intervention Project \u2013 Sarlahi Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Tielsch","sequence":"additional","affiliation":[{"name":"Department of Global Health Milken Institute School of Public Health George Washington University Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,9]]},"container-title":["International Journal of Gynecology & Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijgo.12341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.12341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T22:17:30Z","timestamp":1696025850000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.12341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,9]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/ijgo.12341"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.12341","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,9]]}}}