{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:28:13Z","timestamp":1778898493452,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,18]],"date-time":"2017-11-18T00:00:00Z","timestamp":1510963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,11,18]],"date-time":"2017-11-18T00:00:00Z","timestamp":1510963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess whether endometrial injury in the cycle preceding controlled ovarian hyperstimulation during intracytoplasmic sperm injection (\n                      <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\n                      ) improves the implantation and pregnancy rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between January 1, 2016, and March 31, 2017, a randomized controlled trial was conducted at a center in Egypt among 300 women who met inclusion criteria (first\n                      <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\n                      cycle, aged &lt;40\u00a0years, day\u20103 follicle\u2010stimulating hormone &lt;10\u00a0\n                      <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\n                      \/L, normal serum prolactin, no uterine cavity abnormality). The women were randomly allocated using a web\u2010based system to undergo endometrial scratch in the cycle preceding controlled ovarian hyperstimulation (n=150) or to a control group (n=150). Only data analysts were masked to group assignment. The primary outcomes were the implantation and clinical pregnancy rates at 14\u00a0days and 4\u00a0weeks after embryo transfer, respectively. Analyses were by intention to treat.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The implantation rate was significantly higher in the endometrial scratch group (41.3% [90\/218]) than in the control group (30.0% [63\/210];\n                      <jats:italic>P&lt;<\/jats:italic>\n                      0.001). The clinical pregnancy rate was also significantly higher in the endometrial scratch group (44.2% [61\/138]) than in the control group (30.4% [41\/135];\n                      <jats:italic>P&lt;<\/jats:italic>\n                      0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Endometrial injury in the cycle preceding the stimulation cycle improved implantation and pregnancy rates during\n                      <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ClinicalTrials.gov<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n                      02660125\n         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