{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:58:11Z","timestamp":1783339091159,"version":"3.54.6"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Program for Yangtze River Scholars and Innovative Research Team in University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pregnant women were identified as a population of priority for vaccination during the H1N1 influenza pandemic outbreak in 2009.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess adverse fetal outcomes following the administration of H1N1 pandemic vaccination during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>PubMed, Embase, and Cochrane Library were searched up to January\u00a02017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Cohort studies investigating fetal outcomes after H1N1 influenza vaccination during pregnancy were eligible. The language was limited to English.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Pairs of reviewers independently screened studies for eligibility, assessed the risk of bias, and extracted data from the included studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>A total of 19 cohort studies were eligible. The use of vaccines during any period of pregnancy was associated with lower risk of stillbirth (adjusted hazard ratio 0.80, 95% confidence interval 0.69\u20130.92). No significant differences were found between the vaccinated versus unvaccinated groups in terms of the risks of spontaneous abortion, premature birth, and small for gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The administration of H1N1 vaccines during pregnancy might reduce the risk of stillbirth, a complication associated with H1N1 infection. The quality of evidence was, however, not adequate to reach a definitive conclusion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12394","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T15:16:34Z","timestamp":1510931794000},"page":"141-150","source":"Crossref","is-referenced-by-count":26,"title":["A systematic review and meta\u2010analysis of fetal outcomes following the administration of influenza A\/H1N1 vaccination during pregnancy"],"prefix":"10.1002","volume":"141","author":[{"given":"Chuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Evidence\u2010Based Pharmacy Center West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education  Chengdu China"},{"name":"Department of Obstetrics and Gynecology West China Second University Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Evidence\u2010Based Pharmacy Center West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Evidence\u2010Based Pharmacy Center West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[{"name":"Chinese Evidence\u2010Based Medicine Centre West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61304-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207210"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d3237"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det455"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708630"},{"key":"e_1_2_8_7_1","first-page":"461","article-title":"Vaccine against influenza WHO position paper","volume":"2012","author":"World Health Organization","year":"2012","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.01.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.06.067"},{"issue":"3","key":"e_1_2_8_10_1","first-page":"CD001269","article-title":"Vaccines for preventing influenza in healthy adults","author":"Demicheli V","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12977"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.02.068"},{"key":"e_1_2_8_13_1","unstructured":"EUROCAT Guide1.3 and reference documents\u2014instructions for the registration and Surveillance of Congenital Anomalies issued: September2005. 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