{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:21:25Z","timestamp":1762867285542},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T00:00:00Z","timestamp":1513296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate \u03b2\u2010human chorionic gonadotropin (\u03b2\u2010<jats:styled-content style=\"fixed-case\">HCG<\/jats:styled-content>) level and its 24\u2010hour increment as predictors of successful methotrexate treatment for ectopic pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were retrospectively reviewed from women with ectopic pregnancy who were treated by single\u2010dose methotrexate (50\u00a0mg\/m<jats:sup>2<\/jats:sup>) at a university hospital in Jerusalem, Israel, between January 1, 2000, and June 30, 2015. Serum \u03b2\u2010<jats:styled-content style=\"fixed-case\">HCG<\/jats:styled-content> before treatment and its percentage increment in the 24\u00a0hours before treatment were compared between treatment success and failure groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010nine women were included in the study. Single\u2010dose methotrexate treatment was successful for 44 (63.8%) women. Both mean \u03b2\u2010<jats:styled-content style=\"fixed-case\">HCG<\/jats:styled-content> level and its 24\u2010hour increment were lower for women with successful treatment than for those with failed treatment (respectively, 1224\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\\L vs 2362\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\\L, <jats:italic>P<\/jats:italic>=0.018; and 13.5% vs 29.6%, <jats:italic>P<\/jats:italic>=0.009). Receiver operator characteristic curve analysis yielded cutoff values of 1600\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\\L and 14% increment with a positive predictive value of 75% and 82%, respectively, for treatment success. \u03b2\u2010<jats:styled-content style=\"fixed-case\">HCG<\/jats:styled-content> level and its 24\u2010hour increment were independent predictors of treatment outcome by logistic regression (both <jats:italic>P<\/jats:italic>&lt;0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A \u03b2\u2010<jats:styled-content style=\"fixed-case\">HCG<\/jats:styled-content> increment of less than 14% in the 24\u00a0hours before single\u2010dose methotrexate and serum \u03b2\u2010<jats:styled-content style=\"fixed-case\">HCG<\/jats:styled-content> of less than 1600\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\\L were found to be good predictors of treatment success.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12395","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T10:32:34Z","timestamp":1511173954000},"page":"70-73","source":"Crossref","is-referenced-by-count":16,"title":["Predicting success of methotrexate treatment by pretreatment <scp>HCG<\/scp> level and 24\u2010hour <scp>HCG<\/scp> increment"],"prefix":"10.1002","volume":"141","author":[{"given":"Gabriel","family":"Levin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hadassah University Hospital  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narjes A.","family":"Saleh","sequence":"additional","affiliation":[{"name":"Hadassah University Medical School  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rani","family":"Haj\u2010Yahya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hadassah University Hospital  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liat S.","family":"Matan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hadassah University Hospital  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benshushan","family":"Avi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hadassah University Hospital  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3266-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.07.1775"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3593-x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200304000-00028"},{"key":"e_1_2_7_6_1","first-page":"46","article-title":"Ectopic pregnancy\u2014United States, 1990\u20101992","volume":"44","author":"Centers for Disease Control and Prevention (CDC)","year":"1995","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)05487-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.05.033"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.06.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01547-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4274\/tjod.10576","article-title":"Retrospective analysis of factors that affect the success of single\u2010dose methotrexate treatment in ectopic pregnancy","volume":"12","author":"Var A","year":"2015","journal-title":"Turk J Obstet Gynecol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a135774"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2011.09.023"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.10.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.07.489"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00404-008-0589-4","article-title":"Increment in \u2010hCG in the 48\u2010h period prior to treatment: A new variable predictive of therapeutic success in the treatment of ectopic pregnancy with methotrexate","volume":"278","author":"Costa Soares R","year":"2008","journal-title":"Arch Gynecol Obstet"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.02.007"}],"container-title":["International Journal of Gynecology &amp; 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