{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:20:54Z","timestamp":1762507254175},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672586"],"award-info":[{"award-number":["81672586"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify the clinical characteristics of, and the diagnostic and therapeutic strategies for, gestational trophoblastic neoplasia (<jats:styled-content style=\"fixed-case\">GTN<\/jats:styled-content>) located in the cesarean scar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present retrospective analysis was conducted among patients diagnosed with <jats:styled-content style=\"fixed-case\">GTN<\/jats:styled-content> located in the cesarean scar at Peking Union Medical College Hospital, Beijing, China, between June 1, 2006, and May 31, 2016. Clinical features, diagnostic and therapeutic procedures, and outcomes were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 938 women diagnosed with <jats:styled-content style=\"fixed-case\">GTN<\/jats:styled-content>, 31 (3.3%) patients had <jats:styled-content style=\"fixed-case\">GTN<\/jats:styled-content> located in the cesarean scar. Irregular vaginal bleeding was the main clinical manifestation. Twenty (65%) patients received an accurate diagnosis based on a history of molar pregnancy\/a high \u03b2\u2010human chorionic gonadotropin level\/typical imaging presentations. The remaining 11 patients were initially misdiagnosed; the definitive diagnosis was made by pathology. All patients received chemotherapy; 22 (71%) women also underwent hysterectomy or localized uterine lesion resection because of chemoresistant lesions. All patients had a complete remission; at a median follow\u2010up of 35\u00a0months, only 1 (3%) woman had a relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Owing to its rarity and nonspecific symptoms, <jats:styled-content style=\"fixed-case\">GTN<\/jats:styled-content> located in the cesarean scar is prone to misdiagnosis. In patients without typical manifestations, the definitive diagnosis often relies on pathology. For treatment, uterine lesion resection is a useful adjunct to chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12417","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T04:07:12Z","timestamp":1512619632000},"page":"222-227","source":"Crossref","is-referenced-by-count":9,"title":["Identification and treatment of gestational trophoblastic neoplasia located in the cesarean scar"],"prefix":"10.1002","volume":"141","author":[{"given":"Xiaoyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonglan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xirun","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.06.008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.08.032"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-19-25"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15843"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.08010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.073"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2383-1"},{"key":"e_1_2_8_9_1","first-page":"914","article-title":"Cervicoisthmic choriocarcinoma mimicking cesarean section scar ectopic pregnancy","volume":"18","author":"Sorbi F","year":"2013","journal-title":"J Res Med Sci"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/0100-3984.2015.0073"},{"key":"e_1_2_8_11_1","first-page":"842751","article-title":"Gestational trophoblastic disease: A multimodality imaging approach with impact on diagnosis and management","volume":"2014","author":"Dhanda S","year":"2014","journal-title":"Radiol Res Pract"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt345"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2016.08.819"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2015.58.4.277"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900901)66:5<978::AID-CNCR2820660529>3.0.CO;2-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.04.007"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"43368","DOI":"10.18632\/oncotarget.14727","article-title":"Fertility\u2010sparing uterine lesion resection for young women with gestational trophoblastic neoplasias: Single institution experience","volume":"8","author":"Wang X","year":"2017","journal-title":"Oncotarget"}],"container-title":["International Journal of Gynecology &amp; 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