{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:34:34Z","timestamp":1774272874246,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To evaluate serum human chorionic gonadotropin (HCG<\/jats:styled-content>) levels 0\u20134\u00a0days after single\u2010dose methotrexate administration for tubal ectopic pregnancy.<\/jats:p><\/jats:sec>Methods<\/jats:title>The present retrospective study included women with tubal ectopic pregnancy treated by methotrexate at a tertiary hospital in Hong Kong, China, between January 1, 2007, and December 31, 2016. Patients were stratified serum HCG<\/jats:styled-content> levels rose or fell from day 0\u20134 post\u2010administration. Trends in day 0\u20134 serum HCG<\/jats:styled-content> to predict treatment success were compared with that of day 4\u20137 serum HCG<\/jats:styled-content>. The optimal drop in HCG<\/jats:styled-content> was identified by receiver operating characteristic curve analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 102 patients included. The positive predictive value (PPV<\/jats:styled-content>) of day 0\u20134 serum HCG<\/jats:styled-content> for treatment success was 91% (95% confidence interval [CI<\/jats:styled-content>] 82\u201396), which is comparable to the current criterion of a 15% drop in day 4\u20137 serum HCG<\/jats:styled-content> (PPV<\/jats:styled-content> 91%, 95% CI<\/jats:styled-content> 84\u201395). A 6% drop in day 0\u20134 serum HCG<\/jats:styled-content> was the best predictor of treatment success (PPV<\/jats:styled-content> 96%, 95% CI<\/jats:styled-content> 86\u201399).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>A drop in day 0\u20134 serum HCG<\/jats:styled-content> provided earlier prognostic information and was not inferior to the current criterion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12419","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T05:32:49Z","timestamp":1512624769000},"page":"245-249","source":"Crossref","is-referenced-by-count":12,"title":["Trends in serum human chorionic gonadotropin levels 0\u20134\u00a0days after methotrexate administration for predicting tubal ectopic pregnancy treatment success"],"prefix":"10.1002","volume":"141","author":[{"given":"Lo","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Chinese University of Hong Kong Prince of Wales Hospital Shatin New Territories Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda W.Y.","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Chinese University of Hong Kong Prince of Wales Hospital Shatin New Territories Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Wai","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Chinese University of Hong Kong Prince of Wales Hospital Shatin New Territories Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence T.","family":"Lao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Chinese University of Hong Kong Prince of Wales Hospital Shatin New Territories Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)46349-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00037.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-12-98"},{"key":"e_1_2_7_5_1","first-page":"754","article-title":"Single\u2010dose methotrexate for treatment of ectopic pregnancy","volume":"77","author":"Stovall TG","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del433"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90687-E"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912233412604"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00038.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200304000-00028"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.061"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2602"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.138"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.03.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03133.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-30"}],"container-title":["International Journal of Gynecology & Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijgo.12419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.12419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:13:02Z","timestamp":1695561182000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.12419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,3]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/ijgo.12419"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.12419","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,3]]}}}