{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:52:55Z","timestamp":1767916375280,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,21]],"date-time":"2018-01-21T00:00:00Z","timestamp":1516492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate predictor factors of persistent cytologic dysplasia and\/or high\u2010risk human papillomavirus (hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) infection at 6\u2010month follow\u2010up and at 3\u20135\u00a0years during routine cervical smear testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present retrospective study included data from women treated for cervical dysplasia by large loop excision of the transformation zone (<jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content>) at Ipswich Hospital, <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>, between January 1 and December 31, 2012. Age, parity, smoking, status of resection margins, and previous <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> treatment were evaluated by multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 192 patients included in the study. There was no association between age (relative risk [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>] 1.0, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.80\u20131.23; <jats:italic>P<\/jats:italic>&gt;0.99), smoking (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.12, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.79\u20131.59; <jats:italic>P<\/jats:italic>=0.516), or parity (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.10, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.88\u20131.38; <jats:italic>P<\/jats:italic>=0.382) and abnormal cytology and\/or persistent hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection at 6\u00a0months. There was an association between positive margins (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.64, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.20\u20132.24; <jats:italic>P<\/jats:italic>=0.003), previous <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 3.48, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.69\u20137.15; <jats:italic>P<\/jats:italic>&lt;0.001), and dyskaryosis and\/or hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection at 6\u00a0months. Only previous <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> treatment remained associated with abnormal cytology and persistent hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection at 3\u20135\u00a0years (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 6.37, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.56\u201311.3; <jats:italic>P<\/jats:italic>&lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinical factors, including age, smoking, treatment history, and status of surgical margins, could help to determine the risk of dysplasia recurrence and facilitate patient follow\u2010up based on risk stratification.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12431","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T02:02:39Z","timestamp":1513562559000},"page":"240-244","source":"Crossref","is-referenced-by-count":14,"title":["Risk factors for <scp>HPV<\/scp> persistence and cytology anomalies at follow\u2010up after treatment for cervical dysplasia"],"prefix":"10.1002","volume":"141","author":[{"given":"Ivana","family":"Rizzuto","sequence":"first","affiliation":[{"name":"Department of Gynaecological Oncology Ipswich Hospital  Ipswich UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mythili","family":"Nalam","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology Ipswich Hospital  Ipswich UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology Ipswich Hospital  Ipswich UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Linder","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology Ipswich Hospital  Ipswich UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barnaby","family":"Rufford","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology Ipswich Hospital  Ipswich UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"issue":"12","key":"e_1_2_7_3_1","first-page":"CD006013","article-title":"Interventions for reducing anxiety in women undergoing colposcopy","author":"Galaal K","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-016-0185-7"},{"key":"e_1_2_7_5_1","first-page":"1026","article-title":"Risk factors affecting HPV infection, persistence and lesion progression in women and men","volume":"3","author":"Zitkute V","year":"2016","journal-title":"Clin Res Infect Dis"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0628"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis660"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.089"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70103-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.06.026"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e6855"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.06.021"},{"issue":"1","key":"e_1_2_7_13_1","first-page":"CD010757","article-title":"Follow\u2010up strategies after treatment (large loop excision of the transformation zone (LLETZ) for cervical intraepithelial neoplasia (CIN): Impact of human papillomavirus (HPV) test","author":"Van der Heijden E","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_14_1","unstructured":"NHSCSP.Histopathology Reporting in Cervical Screening \u2013An Integrated Approach. 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