{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:32:58Z","timestamp":1793244778542,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/igo\/legalcode"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Combined oral contraceptives (\n COC<\/jats:styled-content>\n s) containing various progestogens could be associated with differential risks for venous thromboembolism (\n VTE<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To evaluate the comparative risks of\n VTE<\/jats:styled-content>\n associated with the use of low\u2010dose (less than 50\u00a0\u03bcg ethinyl estradiol)\n COC<\/jats:styled-content>\n s containing different progestogens.\n <\/jats:p>\n <\/jats:sec>\n \n Search strategy<\/jats:title>\n PubMed and the Cochrane Library were searched from database inception through September 15, 2016, by combining search terms for oral contraception and venous thrombosis.<\/jats:p>\n <\/jats:sec>\n \n Selection criteria<\/jats:title>\n \n Studies reporting\n VTE<\/jats:styled-content>\n risk estimates among healthy users of progestogen\u2010containing low\u2010dose\n COC<\/jats:styled-content>\n s were included.\n <\/jats:p>\n <\/jats:sec>\n \n Data collection and analysis<\/jats:title>\n \n A random\u2010effects model was used to generate pooled adjusted risk ratios and 95% confidence intervals; subgroup and sensitivity analyses assessed the impact of monophasic\u2010\n COC<\/jats:styled-content>\n use and study\u2010level characteristics.\n <\/jats:p>\n <\/jats:sec>\n \n Main results<\/jats:title>\n \n There were 22 articles included in the analysis. The use of\n COC<\/jats:styled-content>\n s containing cyproterone acetate, desogestrel, drospirenone, or gestodene was associated with a significantly increased risk of\n VTE<\/jats:styled-content>\n compared with the use of levonorgestrel\u2010containing\n COC<\/jats:styled-content>\n s (pooled risk ratios 1.5\u20132.0). The analysis restricted to monophasic\n COC<\/jats:styled-content>\n formulations with 30\u00a0\u03bcg of ethinyl estradiol yielded similar findings. After adjustment for study characteristics, the risk estimates were slightly attenuated.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Compared with the use of levonorgestrel\u2010containing\n COC<\/jats:styled-content>\n s, the use of\n COC<\/jats:styled-content>\n s containing other progestogens could be associated with a small increase in risk for\n VTE<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.12455","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T05:42:52Z","timestamp":1517463772000},"page":"287-294","source":"Crossref","is-referenced-by-count":216,"title":["A systematic review and meta\u2010analysis of venous thrombosis risk among users of combined oral contraception"],"prefix":"10.1002","volume":"141","author":[{"given":"Monica V.","family":"Dragoman","sequence":"first","affiliation":[{"name":"Department of Reproductive Health and Research WHO Geneva 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