{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:14:12Z","timestamp":1792502052010,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T00:00:00Z","timestamp":1521072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It remains unclear which methotrexate protocol for the treatment of ectopic pregnancy has a higher success rate or a higher adverse effect rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the treatment success rates and adverse effect rates of single\u2010dose and non\u2010single\u2010dose (two\u2010dose and multi\u2010dose) methotrexate protocols in the treatment of ectopic pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>Various databases including Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched on July 1, 2017, using search terms including \u201cmethotrexate\u201d and \u201cpregnancy.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Randomized controlled trials comparing different methotrexate protocols for the treatment of ectopic pregnancy were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Relative risks (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>s) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) were calculated to compare treatment success rates and adverse effect rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>The single\u2010dose and non\u2010single\u2010dose protocols had similar success rates (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.00, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.96\u20131.04; 11 trials, 1121 patients, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>=18%). The non\u2010single\u2010dose protocols had a higher adverse effect rate than did the single\u2010dose protocol (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.73, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.59\u20130.91; nine trials, 934 patients, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>=0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The single\u2010dose methotrexate protocol was the optimal protocol for the medical treatment of ectopic pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12473","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T14:04:50Z","timestamp":1519740290000},"page":"295-303","source":"Crossref","is-referenced-by-count":15,"title":["Systematic review and meta\u2010analysis of single\u2010dose and non\u2010single\u2010dose methotrexate protocols in the treatment of ectopic pregnancy"],"prefix":"10.1002","volume":"141","author":[{"given":"Jin\u2010Sung","family":"Yuk","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine Gyeongsang National University Changwon Hospital Gyeongsang National University  Changwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine Gyeongsang National University Changwon Hospital Gyeongsang National University  Changwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won I.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hangang Sacred Heart Hospital School of Medicine Hallym University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong Sik","family":"Ahn","sequence":"additional","affiliation":[{"name":"Institute for Evidence\u2010Based Medicine Department of Preventive Medicine College of Medicine Korea University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute for Evidence\u2010Based Medicine Department of Preventive Medicine College of Medicine Korea University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0810384"},{"key":"e_1_2_7_3_1","unstructured":"Ectopic Pregnancy Mortality \u2014 Florida 2009\u20132010n.d.http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm6106a2.htm. 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