{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T04:23:28Z","timestamp":1695529408381},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001069","name":"Women and Infants Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess umbilical artery lactate levels and perinatal outcomes among women with and without <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present prospective cohort study recruited women planning to undergo vaginal delivery at Kalafong Hospital, South Africa, between March 3 and November 12, 2014. Umbilical artery lactate levels were measured and perinatal outcome data were recorded. Outcome analyses were stratified by maternal <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status, and a subgroup analysis was performed where women with a <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 count below 350\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> cells\/L were compared with women without <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 936 women with singleton fetuses were enrolled. Maternal <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status was available for 897 (95.8%) participants, of whom 202 (21.6%) had <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infections. Overall, 186 (92.1%) women with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infections received prophylaxis or treatment. There was no difference between participants with and without <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infections in the preterm delivery rate (<jats:italic>P<\/jats:italic>=0.770), mode of delivery (<jats:italic>P<\/jats:italic>=0.354), neonatal resuscitation rate (<jats:italic>P<\/jats:italic>=0.717), 1\u2010 or 5\u2010minute Apgar scores below 7 (<jats:italic>P<\/jats:italic>=0.353), or the rate of having an umbilical artery lactate level above 5.45\u00a0mmol\/L (<jats:italic>P<\/jats:italic>=0.301). Similarly, there were no differences in outcomes in the subgroup analysis of women with a <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 count below 350\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> cells\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Umbilical artery lactate levels and perinatal outcomes were found to be\u00a0comparable between patients with and without <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infections in a South African setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12477","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T19:46:39Z","timestamp":1519933599000},"page":"366-370","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of maternal <scp>HIV<\/scp> on umbilical cord lactate measurement at delivery in a South African labor ward"],"prefix":"10.1002","volume":"141","author":[{"given":"Emma R.","family":"Allanson","sequence":"first","affiliation":[{"name":"School of Women's and Infants\u2019 Health Faculty of Medicine, Dentistry, and Health Sciences The University of Western Australia  Crawley WA Australia"},{"name":"SAMRC\/UP Maternal and Infant Health Care Strategies Unit Department of Obstetrics and Gynaecology University of Pretoria  Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Pattinson","sequence":"additional","affiliation":[{"name":"SAMRC\/UP Maternal and Infant Health Care Strategies Unit Department of Obstetrics and Gynaecology University of Pretoria  Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Nathan","sequence":"additional","affiliation":[{"name":"School of Women's and Infants\u2019 Health Faculty of Medicine, Dentistry, and Health Sciences The University of Western Australia  Crawley WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan E.","family":"Dickinson","sequence":"additional","affiliation":[{"name":"School of Women's and Infants\u2019 Health Faculty of Medicine, Dentistry, and Health Sciences The University of Western Australia  Crawley WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132425"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168199"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.06.020405"},{"key":"e_1_2_8_5_1","volume-title":"Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infection in Infants: Recommendations for a Public Health Approach","author":"World Health Organization","year":"2010"},{"key":"e_1_2_8_6_1","volume-title":"Saving Babies 2012\u20132013: Ninth Report on Perinatal Care in South Africa","author":"Pattinson RC","year":"2014"},{"key":"e_1_2_8_7_1","first-page":"227","article-title":"The effect of maternal HIV infection on maternal conditions and perinatal deaths in southwest Tshwane","volume":"2","author":"Pattinson RC","year":"2010","journal-title":"Facts Views Vis Obgyn"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62187-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14306"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1315094"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-009-1107-5"},{"key":"e_1_2_8_12_1","first-page":"23","article-title":"Relationship between HIV serostatus, CD4 count and rehospitalisation: Potential implications for health systems strengthening in South Africa","volume":"32","author":"Moodley Y","year":"2017","journal-title":"S Afr J Infect Dis"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03335.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12132"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2010.01192.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1587-x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32802ef2f6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(16)30195-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2006005000126"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.04.020"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074848"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-0968-y"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001339"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijgo.12477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.12477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:27:13Z","timestamp":1695475633000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.12477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,23]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/ijgo.12477"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.12477","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,23]]},"assertion":[{"value":"2017-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}