{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:29:12Z","timestamp":1792592952119,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To evaluate the usefulness of endocervical curettage (ECC<\/jats:styled-content>) during loop electrosurgical excision procedures (LEEP<\/jats:styled-content>s) in predicting the risk of persistence\/recurrence of cervical intraepithelial neoplasia grade 2 or higher (CIN<\/jats:styled-content>2+) and informing clinical decision\u2010making after LEEP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>The present retrospective study included women undergoing LEEP<\/jats:styled-content> for CIN<\/jats:styled-content>2+ at a teaching hospital in Chile between January 1, 2007, and December 31, 2014. Demographic, pathologic, and follow\u2010up data were collected. Associations between predictors and treatment failure (persistent\/recurrent disease) were examined; a Cox model was used to assess the effects of different variables on the failure rate.<\/jats:p><\/jats:sec>Results<\/jats:title>The analysis included 330 women with a mean follow\u2010up of 29.4\u00a0months; 188 women underwent ECC<\/jats:styled-content> at the time of LEEP<\/jats:styled-content>. On multivariate analysis, a positive ECC<\/jats:styled-content> was the only variable significantly associated with persistence\/recurrence (P<\/jats:italic>=0.001). In the Cox model, positive ECC<\/jats:styled-content> (P<\/jats:italic>=0.001) and positive margins (P<\/jats:italic>=0.009) were independently associated with higher failure rates. When faced with positive ECC<\/jats:styled-content> findings, clinicians tended to perform additional treatment instead of advising follow\u2010up.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Positive findings from ECC<\/jats:styled-content> performed during LEEP<\/jats:styled-content> were a better predictor of persistent\/recurrent disease than margin status, after adjusting the individual variable effect in the Cox modelling. The performance of ECC<\/jats:styled-content> is recommended during any LEEP<\/jats:styled-content> performed for CIN<\/jats:styled-content>2+; in particular, it should never be omitted if endocervical disease is suspected.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12480","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T18:02:39Z","timestamp":1520359359000},"page":"337-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The value of endocervical curettage during loop electrosurgical excision procedures in predicting persistent\/recurrent preinvasive cervical disease"],"prefix":"10.1002","volume":"141","author":[{"given":"Mauricio A.","family":"Cuello","sequence":"first","affiliation":[{"name":"Division of Obstetrics and Gynecology School of Medicine Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago 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