{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:02:09Z","timestamp":1762210929369},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T00:00:00Z","timestamp":1524528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess whether women with HIV who had low\u2010grade squamous intraepithelial lesions (LSIL) on cytology had cervical disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present retrospective cross\u2010sectional study included data from women with LSIL who attended a tertiary hospital in South Africa between April 1, 2003, and December 31, 2013. Patient information was extracted from a colposcopy database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 652 patients. The median age was 36\u00a0years (interquartile range [IQR] 31\u201342\u00a0years; range 18\u201366\u00a0years) and the median parity was three (IQR 2\u20135; range 0\u201310). In all, 266 (40.8%) women had a histology result of HPV or cervical intraepithelial neoplasia 1 (CIN1); 386 (59.2%) had a histology result of CIN2 or higher. The median cluster of differentiation 4 (CD4) count was 275.00 cells\/mm<jats:sup>3<\/jats:sup> (IQR 173.50\u2013434.00 cells\/mm<jats:sup>3<\/jats:sup>; range 2\u20131211 cells\/mm<jats:sup>3<\/jats:sup>). A total of 312 (47.9%) women were using antiretroviral therapy. Use of antiretroviral therapy (unadjusted odds ratio 0.57; <jats:italic>P<\/jats:italic>=0.001) and a CD4 count of at least 200 cells\/mm<jats:sup>3<\/jats:sup> (unadjusted odds ratio 0.81; <jats:italic>P<\/jats:italic>=0.002) were associated with a histology result of HPV or CIN1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most of the women with a cytology report of LSIL had CIN2 or higher, suggesting that the practice of referral for colposcopy should continue.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12505","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T01:24:37Z","timestamp":1523409877000},"page":"78-83","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Low\u2010grade squamous intraepithelial lesions among women with HIV"],"prefix":"10.1002","volume":"142","author":[{"given":"Portia K.","family":"Manamela","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chris Hani Baragwanath Academic Hospital  Johannesburg South Africa"},{"name":"School of Clinical Medicine University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koena A.","family":"Kgomo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chris Hani Baragwanath Academic Hospital  Johannesburg South Africa"},{"name":"School of Clinical Medicine University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril J.","family":"van Gelderen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chris Hani Baragwanath Academic Hospital  Johannesburg South Africa"},{"name":"School of Clinical Medicine University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anushka R.","family":"Lekha","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chris Hani Baragwanath Academic Hospital  Johannesburg South Africa"},{"name":"School of Clinical Medicine University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Michelow","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine University of the Witwatersrand  Johannesburg South Africa"},{"name":"Department of Anatomical Pathology Faculty of Health Science National Health Laboratory Service  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunice J.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine University of the Witwatersrand  Johannesburg South Africa"},{"name":"Department of Anatomical Pathology Faculty of Health Science National Health Laboratory Service  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chris Hani Baragwanath Academic Hospital  Johannesburg South Africa"},{"name":"School of Clinical Medicine University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24067"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/520022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-135"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(69)90268-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.111791"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.10.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199809000-00013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000428"},{"key":"e_1_2_7_10_1","first-page":"CD009836","article-title":"Immediate referral to colposcopy versus cytological surveillance for minor cervical cytological abnormalities in the absence of HPV test","author":"Kyrgiou M","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2010.01170.x"},{"key":"e_1_2_7_12_1","unstructured":"National Department of Health.Cervical Cancer Policy.2017.http:\/\/www.health.gov.za\/index.php\/shortcodes\/2015-03-29-10-42-47\/2015-04-30-08-18-10\/2015-04-30-08-24-27. Accessed September 17 2017."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(85)80244-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.pubmed.a024671"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1989.tb03382.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2012.09.022"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328340fd99"},{"key":"e_1_2_7_19_1","first-page":"3","article-title":"Human papilloma virus infections and disease in HIV","volume":"21","author":"Clark R","year":"2009","journal-title":"HIV Clin"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-211"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1258\/095646206778145703"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03444.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.5050"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijgo.12505","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.12505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:22:37Z","timestamp":1695471757000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.12505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,24]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/ijgo.12505"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.12505","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,24]]},"assertion":[{"value":"2017-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}