{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T18:28:13Z","timestamp":1717007293232},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare transvaginal ultrasonography and hysteroscopy for the diagnosis of endometrial pathologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present retrospective cohort study, data were reviewed from women with ultrasonography findings suggestive of endometrial lesions and\/or abnormal uterine bleeding who underwent hysteroscopy at a single center in Campinas, Brazil, between January 2011 and December 2013; data were stratified based on reproductive\u2010aged and postmenopausal groups. The accuracy, sensitivity, specificity, positive predictive value (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>), and negative predictive value (<jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content>) of ultrasonography and hysteroscopy for the diagnosis of endometrial lesions were determined. Histopathology was used as the gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 754 patients included (256 reproductive age, 498 postmenopausal). In the reproductive\u2010age group, ultrasonography had a sensitivity of 96.0%, specificity of 58.0%, <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> of 94.4%, <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> of 66.6%, and accuracy of 91.5%, whereas hysteroscopy had a sensitivity of 91.8%, specificity of 76.6%, <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> of 96.0%, <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> of 60.5%, and accuracy of 89.7% for the diagnosis of endometrial disease. In the postmenopausal group, ultrasonography had a sensitivity of 99.0%, specificity of 19.0%, <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> of 96.1%, <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> of 50.0%, and accuracy of 95.3%, whereas hysteroscopy had a sensitivity of 96.7%, specificity of 86.9%, <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> of 99.2%, <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> of 58.8%, and accuracy of 96.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ultrasonography was found to be an effective method for the diagnosis of endometrial disease, especially among postmenopausal 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