{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T14:25:58Z","timestamp":1785594358327,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare clinical and obstetric adverse events among pregnant women with sickle cell disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>) according to genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present cross\u2010sectional study enrolled women aged 15\u201349\u00a0years with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> and prior pregnancy attending a hematology center in Recife, Brazil, between September 1, 2015, and April 30, 2016. Associations between sickle cell genotype (Hb<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>, Hb<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>, S\u03b2\u2010thalassemia) and adverse events were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 89 women were included; 74 (83%) had Hb<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> genotype, 8 (9%) had Hb<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> genotype, and 7 (8%) had S\u03b2\u2010thalassemia genotype. Fifty\u2010three (60%) self\u2010reported being of mixed race, and 27 (30%) self\u2010reported they were black. Blood transfusion was observed more frequently among women with Hb<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> than among those with Hb<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> genotype (<jats:italic>P<\/jats:italic>=0.007). Postpartum adverse events were more frequent in the S\u03b2\u2010thalassemia than in the Hb<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>=0.030). Fetal intrauterine death occurred only among women with the Hb<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> genotype (11 [15%]). In the Hb<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> group, there was a higher frequency of blood transfusion (<jats:italic>P<\/jats:italic>=0.004) and lower rate of spontaneous abortion (<jats:italic>P<\/jats:italic>=0.001) among women with six or more consultations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Hb<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> genotype was associated with a higher frequency of blood transfusion. S\u03b2\u2010thalassemia was associated with a higher frequency of postpartum adverse events. Prenatal care was associated with a lower rate of spontaneous abortion in the Hb<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12626","type":"journal-article","created":{"date-parts":[[2018,7,21]],"date-time":"2018-07-21T14:44:08Z","timestamp":1532184248000},"page":"89-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Adverse clinical and obstetric outcomes among pregnant women with different sickle cell disease genotypes"],"prefix":"10.1002","volume":"143","author":[{"given":"Fl\u00e1via A.C.","family":"Silva","sequence":"first","affiliation":[{"name":"Instituto de Medicina Integral Prof. Fernando Figueira  Recife Brazil"},{"name":"Faculdade Pernambucana de Sa\u00fade  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.C.G.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Prof. Fernando Figueira  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela F.","family":"Hazin\u2010Costa","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Prof. Fernando Figueira  Recife Brazil"},{"name":"Hematology Department at Universidade Federal de Pernambuco  Recife Brazil"},{"name":"Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina L.G.","family":"Dias","sequence":"additional","affiliation":[{"name":"Faculdade Pernambucana de Sa\u00fade  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aderson S.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariani I.","family":"Souza","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Prof. Fernando Figueira  Recife Brazil"},{"name":"Faculdade Pernambucana de Sa\u00fade  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.11-0625"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.036673"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2010.02.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12780"},{"key":"e_1_2_8_6_1","first-page":"405","article-title":"Maternal and perinatal outcomes in pregnancies complicated by sickle cell diseases","volume":"32","author":"Nomura RMY","year":"2010","journal-title":"Rev Bras Ginecol Obstet"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-607317"},{"key":"e_1_2_8_8_1","unstructured":"VichinskyEP.Pregnancy in women with sickle cell disease.UpToDate.2016:1\u201319. 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