{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:35:36Z","timestamp":1770842136272,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T00:00:00Z","timestamp":1536364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011072","name":"Center for AIDS Research, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare accuracy of detecting high\u2010grade cervical lesions (squamous intraepithelial lesions or greater, <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>+) by high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> messenger <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>) testing between physician\u2010 and self\u2010collected specimens, and by conventional cytology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present prospective longitudinal study included data collected among female sex workers (<jats:styled-content style=\"fixed-case\">FSW<\/jats:styled-content>s) in Nairobi, Kenya, between December 2, 2009, and February 15, 2013. Participants self\u2010collected cervico\u2010vaginal specimens for hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> testing, and a physician collected cervical specimens for hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> testing and conventional cytology. hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> testing was conducted every 3\u00a0months, and conventional cytology every 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 350 <jats:styled-content style=\"fixed-case\">FSW<\/jats:styled-content>s aged 18\u201350\u00a0years participated. hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> prevalence decreased slightly from 29.9% (103\/344) at baseline to 24.3% (53\/218) at 24\u00a0months for physician\u2010collected, and 28.5% (98\/344) to 24.3% (53\/218) for self\u2010collected specimens. Agreement between the sampling methods appeared to increase over time (baseline <jats:italic>\u03ba<\/jats:italic> 0.55, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.45\u20130.65; 24\u00a0months <jats:italic>\u03ba<\/jats:italic> 0.83, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.74\u20130.91). Among 21 patients with <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>+ over 24\u00a0months, 18 (86%) and 17 (81%) had hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010positive results at baseline in physician\u2010 and self\u2010collected specimens, respectively; and 20 (95%) had baseline hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010positive results or cytology anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall agreement between physician\u2010 and self\u2010collected hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> results was moderate and appeared to increase over time. Baseline physician\u2010 and self\u2010collected hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> tests were similarly strong indicators of cumulative <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>+ over 24\u00a0months.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12628","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T13:43:36Z","timestamp":1532612616000},"page":"217-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["High\u2010risk <scp>HPV<\/scp>\u2010<scp>RNA<\/scp> screening of physician\u2010 and self\u2010collected specimens for detection of cervical lesions among female sex workers in Nairobi, Kenya"],"prefix":"10.1002","volume":"143","author":[{"given":"Virginia","family":"Senkomago","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of North Carolina  Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of California  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessie","family":"Kwatampora","sequence":"additional","affiliation":[{"name":"Institute of Tropical and Infectious Diseases University of Nairobi\/Kenyatta National Hospital University of Nairobi  Nairobi Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Gukare","sequence":"additional","affiliation":[{"name":"Institute of Tropical and Infectious Diseases University of Nairobi\/Kenyatta National Hospital University of Nairobi  Nairobi Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelly","family":"Mugo","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute  Nairobi Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Kimani","sequence":"additional","affiliation":[{"name":"Institute of Tropical and Infectious Diseases University of Nairobi\/Kenyatta National Hospital University of Nairobi  Nairobi Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina  Chapel Hill NC USA"},{"name":"Lineberger Comprehensive Cancer Center  Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,8]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11","author":"Ferlay 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