{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:20:12Z","timestamp":1758925212915},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the usefulness of Doppler indices of the corpus luteum and uterine artery in combination with serum progesterone and cancer antigen 125 (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>125) as prognostic tools in first\u2010trimester threatened spontaneous abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnant women with threatened spontaneous abortion at a pregnancy duration 8\u201310\u00a0weeks were enrolled into an observational prospective clinical trial at a university hospital in Egypt during 2015. Doppler indices (uterine artery\/corpus luteum resistance index and pulsatility index) and biochemical markers (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>125, progesterone) were determined and compared by pregnancy outcome (spontaneous abortion vs continuing pregnancy at 20\u00a0weeks).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 100 women included, 16 had a spontaneous abortion. These women had a higher <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>125 value than did women without an abortion (<jats:italic>P<\/jats:italic>&lt;0.001), whereas the progesterone level among women with an abortion was lower (<jats:italic>P<\/jats:italic>&lt;0.001). The Doppler indices were not significantly different between the groups, but calculation of the uterine artery resistance index as a percentage of the normal standard value at a given pregnancy duration revealed significant differences (<jats:italic>P<\/jats:italic>&lt;0.001) between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum progesterone and <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>125 are useful provisional predictors of spontaneous abortion, whereas the Doppler indices are not. The two biomarkers could be used as a basis to counsel anxious couples.<\/jats:p><\/jats:sec><jats:sec><jats:title>ClinicalTrials.gov<\/jats:title><jats:p>NCT02420769.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12631","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T04:24:33Z","timestamp":1532924673000},"page":"150-155","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Doppler and biochemical assessment for the prediction of early pregnancy outcome in patients experiencing threatened spontaneous abortion"],"prefix":"10.1002","volume":"143","author":[{"given":"Nesreen A.A.","family":"Shehata","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Beni Suef University  Beni Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamada A.A.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Obstetrics 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