{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:07:11Z","timestamp":1776258431719,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Various adjuvant therapies have failed to improve clinical symptoms and pregnancy rates among patients with moderate\u2010to\u2010severe intrauterine adhesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the ability of amniotic membrane to prevent the recurrence of intrauterine adhesion after hysteroscopic adhesiolysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>The Cochrane Library, Embase, and PubMed databases were searched for articles published before December 31, 2017, using the terms: (\u201camnion\u201d) and (\u201cintrauterine adhesions\u201d or \u201cAsherman syndrome\u201d or \u201c<jats:styled-content style=\"fixed-case\">IUA<\/jats:styled-content>\u201d or \u201cendometrial injury\u201d or \u201cuterine adhesion\u201d or \u201chysteroscopic\u201d or \u201chysteroscopic adhesiolysis\u201d).<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Randomized controlled trials of amniotic membrane therapy after hysteroscopic adhesiolysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Four studies were included in the meta\u2010analysis (300 patients in total). Dichotomous outcomes were expressed as relative risk (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) with 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s). Continuous variables were expressed as mean difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Amniotic membrane increased menstrual blood volume after hysteroscopic adhesiolysis (mean difference 6.15, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4.20\u20138.11; <jats:italic>P<\/jats:italic>&lt;0.001). By contrast, this treatment did not affect the rates of intrauterine adhesion recurrence (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.84, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.61\u20131.16; <jats:italic>P<\/jats:italic>=0.290); pregnancy (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.40, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.78\u20132.50; <jats:italic>P<\/jats:italic>=0.260); or spontaneous abortion (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.88, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.38\u20131.99; <jats:italic>P<\/jats:italic>=0.750).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of amniotic membrane increased menstrual blood volume but failed to improve other measures assessed in the current meta\u2010analysis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12635","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T04:08:50Z","timestamp":1533614930000},"page":"145-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Meta\u2010analysis of the use of amniotic membrane to prevent recurrence of intrauterine adhesion after hysteroscopic adhesiolysis"],"prefix":"10.1002","volume":"143","author":[{"given":"Fei","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Yiwu Maternity and Children Hospital  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yiwu Maternity and Children Hospital  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Public Health Southwest Medical University  Lu Zhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yiwu Maternity and Children Hospital  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuechong","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Human Health and Human Services Yiwu Maternity and Children Hospital  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2016.10.018"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-198606000-00025"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.02.113"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh238"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000378"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.18643\/gieu.2016.166"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2017.09.020"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1328050"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.11.040"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.07.018"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2006.00454.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)59942-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1990.tb16249.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","unstructured":"HigginsJPT GreenS.Cochrane handbook for systematic reviews of interventions. 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