{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:11:46Z","timestamp":1763017906976},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To evaluate sentinel lymph node (SLN<\/jats:styled-content>) mapping for endometrial cancer, using radioisotope and indocyanine green (ICG<\/jats:styled-content>) injections.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective study was conducted between April 1, 2014, and December 27, 2017, among women with endometrial cancer, excluding those with suspected peritoneal dissemination and lymph node metastasis, at a University hospital in Kagoshima, Japan. Patients with low\u2010risk endometrial cancer underwent pelvic SLN<\/jats:styled-content> mapping using uterine cervix radioisotope injections; intermediate\/high\u2010risk patients underwent pelvic SLN<\/jats:styled-content> with\/without intraoperative para\u2010aortic SLN<\/jats:styled-content> mapping with ICG<\/jats:styled-content> subserosal injections. Primary endpoints were estimated detection rates, sensitivity, and negative predict values (NPV<\/jats:styled-content>) of SLN<\/jats:styled-content> mapping.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 113 patients evaluated, comprehensive pelvic lymphadenectomy was performed after SLN<\/jats:styled-content> detection in all patients; additional para\u2010aortic lymphadenectomy was performed in 38 (34%) patients. The detection rates for pelvic SLN<\/jats:styled-content> (\u22651), bilateral pelvic SLN<\/jats:styled-content>, and para\u2010aortic SLN<\/jats:styled-content> (\u22651) were 96%, 80%, and 55%, respectively. Pelvic and para\u2010aortic lymph node metastasis were found in (10%) (12\/113) and 18% (6\/33) patients, respectively. Isolated para\u2010aortic lymph node metastasis was not observed. In pelvic SLN<\/jats:styled-content> analysis, sensitivity was 91% and NPV<\/jats:styled-content> was 99%. In para\u2010aortic SLN<\/jats:styled-content> analysis, sensitivity and NPV<\/jats:styled-content> were 100%.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>SLN<\/jats:styled-content> biopsy may be useful to avoid comprehensive pelvic lymphadenectomy in low\u2010risk patients. In high\u2010risk patients, SLN<\/jats:styled-content> mapping revealed high detection rates, sensitivity, and NPV<\/jats:styled-content>, including those for para\u2010aortic SLN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12651","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T15:11:31Z","timestamp":1534950691000},"page":"313-318","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prospective study of sentinel lymph node mapping for endometrial cancer"],"prefix":"10.1002","volume":"143","author":[{"given":"Shinichi","family":"Togami","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Kagoshima University Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology 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