{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:46:16Z","timestamp":1792593976299,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>To determine the relationship between maternal serum uric acid levels and fetal\/neonatal complications in women with pre\u2010eclampsia\/eclampsia, and to establish a predictive threshold value.<\/jats:p><\/jats:sec>Methods<\/jats:title>A diagnostic test and historical cohort study conducted by prospective cross\u2010sectional data collection on pregnant women with pre\u2010eclampsia\/eclampsia at Hue University Hospital, Vietnam, between March 2015 and July 2017. Pre\u2010eclampsia was diagnosed based on ACOG<\/jats:styled-content> criteria. Serum uric acid levels were measured by enzymatic colorimetric testing using a Cobas c 501 analyzer (Roche Diagnostics, Mannheim, Germany). Fetal complications included intrauterine growth restriction, preterm delivery, fetal death, and neonatal death.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 205 women enrolled. Serum uric acid at a cutoff of 393\u00a0\u03bcmol\/L is a good predictor of fetal\/neonatal complications (AUC<\/jats:styled-content> 0.752), with 64.4% sensitivity and 79.5% specificity. High uric acid level (\u2265393\u00a0\u03bcmol\/L) resulted in increased risk of preterm birth (OR<\/jats:styled-content> 6.367, 95% CI<\/jats:styled-content> 3.009\u201313.084), low Apgar scores (OR<\/jats:styled-content> 5.514, 95% CI<\/jats:styled-content> 1.877\u201316.198), intrauterine growth restriction (OR<\/jats:styled-content> 7.188, 95% CI<\/jats:styled-content> 3.592\u201314.382), and neonatal death (OR<\/jats:styled-content> 7.818, 95% CI<\/jats:styled-content> 1.614\u201337.867). There was no relationship between uric acid level and fetal death (OR<\/jats:styled-content> 1.803, 95% CI<\/jats:styled-content> 0.355\u20139.168).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Maternal serum uric acid concentration is a good predictor of fetal\/neonatal outcomes in women with pre\u2010eclampsia\/eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12697","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T12:54:19Z","timestamp":1540385659000},"page":"21-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Maternal serum uric acid concentration and pregnancy outcomes in women with pre\u2010eclampsia\/eclampsia"],"prefix":"10.1002","volume":"144","author":[{"given":"Tam M.","family":"Le","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hue University of Medicine and Pharmacy Hue University Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long H.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hue University of Medicine and Pharmacy Hue University Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam L.","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hue University of Medicine and Pharmacy Hue University Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong D.","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Public Health Hue University of Medicine and Pharmacy Hue University Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy V.Q.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hue University of Medicine and Pharmacy Hue University Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinh Q.","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hue University of Medicine and Pharmacy Hue University Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh N.","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hue University of Medicine and Pharmacy Hue University Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000069700.62727.C5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.11.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"e_1_2_8_5_1","first-page":"7","article-title":"Blood uric acid level as a marker 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