{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:01:17Z","timestamp":1767135677842,"version":"build-2238731810"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the effectiveness of using glacial acetic acid (GAA) to convert unsatisfactory bloody ThinPrep (TP) cervical smear test to satisfactory, and identify associated missed diagnoses and high\u2010risk HPV (hrHPV) genotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a retrospective descriptive cross\u2010sectional analysis, all TP tests performed in Mississippi, USA, 2012\u20132016, were evaluated for unsatisfactory results owing to blood. Tests that were converted to satisfactory by GAA treatment, and corresponding anomalies and HPV genotypes were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 106\u00a0384 TP tests, there were 1460 (1.37%) unsatisfactory results, of which 1442 (98.77%) were converted to satisfactory after GAA treatment. Laboratory preprocessing with GAA increased costs minimally. Precancerous lesions were detected in 166 (11.51%) of 1442 GAA\u2010treated samples, of which 12 (7.2%) were high\u2010grade lesions, 110 (66.3%) were atypical squamous cells of undetermined significance, and 63 (57.3%) tested positive for hrHPV. Of 60 genotyped samples, 39 (65%) had non\u2010HPV16 and non\u2010HPV18. Including mixed infections, 48 (80%) contained less\u2010common hrHPV types, reflecting an unexpected distribution in bloody specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GAA pretreatment of bloody TP tests would reduce the incidence of unsatisfactory results and missed high\u2010grade lesions, and prevent the cost of repeat tests and delayed treatment. Clinicians without access to GAA should consider HPV\u00a0testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.12699","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T03:14:04Z","timestamp":1540523644000},"page":"85-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Precancerous cervical lesions and HPV genotypes identified in previously unsatisfactory cervical smear tests after inexpensive glacial acetic acid processing"],"prefix":"10.1002","volume":"144","author":[{"given":"Carolann","family":"Risley","sequence":"first","affiliation":[{"name":"School of Graduate Studies and School of Nursing University of Mississippi Medical Center  Jackson MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim R.","family":"Geisinger","sequence":"additional","affiliation":[{"name":"School of Graduate Studies and School of Nursing University of Mississippi Medical Center  Jackson MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer C.","family":"Robinson","sequence":"additional","affiliation":[{"name":"School of Graduate Studies and School of Nursing University of Mississippi Medical Center  Jackson MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary W.","family":"Stewart","sequence":"additional","affiliation":[{"name":"School of Graduate Studies and School of Nursing University of Mississippi Medical Center  Jackson MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Graduate Studies and School of Nursing University of Mississippi Medical Center  Jackson MI USA"},{"name":"Mississippi State Department of Health  Jackson MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda","family":"Alexander","sequence":"additional","affiliation":[{"name":"School of Graduate Studies and School of Nursing University of Mississippi Medical Center  Jackson MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen S.","family":"Raab","sequence":"additional","affiliation":[{"name":"School of Graduate Studies and School of Nursing University of Mississippi Medical Center  Jackson MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1309\/XMQP-9AJD-104W-07C8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20152"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20437"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21271"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP8N9ZJQDHFYTC"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325921"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/1742-6413.168060"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23426"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20890"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22904"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1309\/GE86-156K-EGM2-DGXB"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11932"},{"key":"e_1_2_7_14_1","unstructured":"Signs and Symptoms of Cervical Cancer.American Cancer Society website. 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