{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:17Z","timestamp":1786977857877,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"La Roche sur Yon Hospital"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n To determine maternal and biological parameters at diagnosis of gestational diabetes mellitus (\n GDM<\/jats:styled-content>\n ) as predictors of antenatal insulin therapy (\n AIT<\/jats:styled-content>\n ) for glycemic control.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this planned secondary analysis of a prospective observational study, we recruited women diagnosed with\n GDM<\/jats:styled-content>\n between July 1, 2014, and October 31, 2015. Maternal and biological parameters were analyzed as predictors of\n AIT<\/jats:styled-content>\n using multivariable logistic regression analyses. Predictive accuracy of a cut\u2010off value for a biological predictor was determined using the area under the receiver operating characteristic curve (\n AUC<\/jats:styled-content>\n ) and the Youden index (J).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 200 women included (mean gestational age 22\u00a0\u00b1\u00a06\u00a0weeks), 72 (36%) required\n AIT<\/jats:styled-content>\n . No maternal characteristic was associated with\n AIT<\/jats:styled-content>\n . Glycated hemoglobin (HbA1c; adjusted odds ratio [\n aOR<\/jats:styled-content>\n ] 3.15, 95%\n CI<\/jats:styled-content>\n 1.03\u20139.69) and elevated 1\u2010hour oral glucose tolerance test (\n OGTT<\/jats:styled-content>\n ;\n aOR<\/jats:styled-content>\n 1.23, 95%\n CI<\/jats:styled-content>\n 1.13\u20131.46) were predictors of\n AIT<\/jats:styled-content>\n . Analyses suggested inaccurate prediction of\n AIT<\/jats:styled-content>\n , with an optimal cut\u2010off HbA1c value of 5.4% (J=0.14;\n AUC<\/jats:styled-content>\n 0.58, 95%\n CI<\/jats:styled-content>\n 0.48\u20130.67), and an optimal 1\u2010hour plasma glucose\n OGTT<\/jats:styled-content>\n value of 1.77\u00a0mg\/\n dL<\/jats:styled-content>\n (J=0.24;\n AUC<\/jats:styled-content>\n 0.62, 95%\n CI<\/jats:styled-content>\n 0.50\u20130.74).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n HbA1c at diagnosis of\n GDM<\/jats:styled-content>\n and elevated 1\u2010hour\n OGTT<\/jats:styled-content>\n were independent predictors of\n AIT<\/jats:styled-content>\n for glycemic control.\n <\/jats:p>\n \n Clinicaltrials.gov:<\/jats:bold>\n NCT<\/jats:styled-content>\n 02159378.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.12753","type":"journal-article","created":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T10:48:23Z","timestamp":1545475703000},"page":"265-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Predictive factors of subsequent insulin requirement for glycemic control during pregnancy at diagnosis of gestational diabetes mellitus"],"prefix":"10.1002","volume":"144","author":[{"given":"Guillaume","family":"Ducarme","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Centre Hospitalier Departemental La Roche sur Yon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Desroys du Roure","sequence":"additional","affiliation":[{"name":"Department of Biology Centre Hospitalier Departemental La Roche sur Yon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9phine","family":"Grange","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Centre Hospitalier Departemental La Roche sur Yon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Vital","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Centre Hospitalier Departemental La Roche sur Yon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Le Thuaut","sequence":"additional","affiliation":[{"name":"Clinical Research Center Centre Hospitalier Departemental La Roche sur Yon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Crespin\u2010Delcourt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Centre Hospitalier Departemental La Roche sur Yon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,11]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"S338","article-title":"Coll\u00e8ge national des gyn\u00e9cologues et obst\u00e9triciens fran\u00e7ais; Soci\u00e9t\u00e9 francophone du diab\u00e8te. 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