{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:39Z","timestamp":1786977879862,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2019,4]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n To evaluate the association between\n CD<\/jats:styled-content>\n 16\n ++<\/jats:sup>\n monocytes in peripheral blood and the clinical features and short\u2010term therapeutic effects of polycystic ovary syndrome\u00a0(\n PCOS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This prospective cross\u2010sectional study included women diagnosed with\n PCOS<\/jats:styled-content>\n at a University Hospital in Shanghai, China, between June 4 and November 28, 2016. Patients received Diane\u201035, metformin, or both combined for 3\u00a0months. We collected anthropometric measures and used flow cytometry to detect\n CD<\/jats:styled-content>\n 16\n ++<\/jats:sup>\n monocytes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The final analysis included 70 patients: 18 in the Diane\u201035 group, 30 in the metformin group, and 22 in the Diane\u201035 plus metformin group. The control group comprised 60 women without\n PCOS<\/jats:styled-content>\n . The proportion of\n CD<\/jats:styled-content>\n 16\n ++<\/jats:sup>\n monocytes was significantly higher in patients with\n PCOS<\/jats:styled-content>\n than in those with no\n PCOS<\/jats:styled-content>\n (16.05% vs 10.73%;\n P<\/jats:italic>\n =0.001). The proportion differed significantly between patients with and those without hyperandrogenism (13.12% vs 17.30%;\n P<\/jats:italic>\n =0.002) and showed moderate accuracy in diagnosing hyperandrogenism before treatment. We noted a decrease in monocytes post\u2010treatment in patients given metformin and Diane\u201035 plus metformin.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The proportion of\n CD<\/jats:styled-content>\n 16\n ++<\/jats:sup>\n monocytes was most significantly associated with hyperandrogenism before treatment. Our findings suggest that the proportion of\n CD<\/jats:styled-content>\n 16\n ++<\/jats:sup>\n monocytes in peripheral blood might be related to the inflammatory condition of\n PCOS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.12779","type":"journal-article","created":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T08:09:23Z","timestamp":1549094963000},"page":"12-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between\n CD<\/scp>\n 16\n ++<\/sup>\n monocytes in peripheral blood and clinical features and short\u2010term therapeutic effects of polycystic ovary syndrome"],"prefix":"10.1002","volume":"145","author":[{"given":"Lingli","family":"Tang","sequence":"first","affiliation":[{"name":"Laboratory for Reproductive Immunology Hospital and Institute of Obstetrics and Gynecology Shanghai Medical School Fudan University Shanghai 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