{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:31:34Z","timestamp":1788449494189,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess three\u2010dimensional (3D) ultrasound combined with power Doppler (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) for the differential diagnosis of endometrial lesions among infertile women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study carried out at a reproductive medicine center in Luoyang, China, between January and December 2015. The inclusion criteria were asymptomatic infertility with normal endometrium or specific endometrial lesions. Participants were subdivided by whether they had normal endometrium (group 1, n=357), or endometrial lesions including polyps, hyperplasia, intrauterine adhesions, or endometritis (group 2, n=99). 3D <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and hysteroscopy were performed in the follicular phase. Endometrial thickness, volume, vascularization index (<jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>), flow index (<jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>), and vascularization flow index (<jats:styled-content style=\"fixed-case\">VFI<\/jats:styled-content>), and subendometrial <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FI<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">VFI<\/jats:styled-content> were calculated. Endometrial lesions were confirmed by pathologic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall prevalence of endometrial lesions was 99\/456 (21.3%). Endometrial thickness and volume were significantly larger in group 2 than in group 1 (9.96\u00a0\u00b1\u00a03.24 vs 8.15\u00a0\u00b1\u00a02.50\u00a0mm and 3.70\u00a0\u00b1\u00a02.54 vs 2.42\u00a0\u00b1\u00a01.64\u00a0cm<jats:sup>3<\/jats:sup>, respectively; both <jats:italic>P<\/jats:italic>&lt;0.001). Endometrial thickness and volume were larger among women with endometrial polyps and hyperplasia; endometrial <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FI<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">VFI<\/jats:styled-content> were lower among women with intrauterine adhesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Three\u2010dimensional <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> has value for the differential diagnosis of endometrial lesions among infertile women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p>The trial is registered in the Chinese Clinical Trial Registry as\u00a0Chi<jats:styled-content style=\"fixed-case\">CTR<\/jats:styled-content>1800015799.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12787","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T17:22:14Z","timestamp":1550164934000},"page":"212-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Three\u2010dimensional 3D ultrasound combined with power Doppler for the differential diagnosis of endometrial lesions among infertile women"],"prefix":"10.1002","volume":"145","author":[{"given":"Jia","family":"Ni","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center Luoyang Central Hospital Affiliated to Zhengzhou University  Luoyang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Han","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Luoyang Central Hospital Affiliated to Zhengzhou University  Luoyang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabin","family":"Liang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Luoyang Central Hospital Affiliated to Zhengzhou University  Luoyang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Luoyang Central Hospital Affiliated to Zhengzhou University  Luoyang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu047"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.05.003"},{"issue":"641","key":"e_1_2_7_4_1","first-page":"xi","article-title":"Office hysteroscopy","volume":"31","author":"Bettocchi S","year":"2004","journal-title":"Obstet Gynecol Clin North Am"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.06.044"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181f0df98"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7470"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00533-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2628"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.14020139.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.09.039"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(96)01064-X"},{"issue":"5","key":"e_1_2_7_13_1","first-page":"CD011126","article-title":"Three\u2010dimensional saline infusion sonography compared to two\u2010dimensional saline infusion sonography for the diagnosis of focal intracavitary lesions","author":"Nieuwenhuis LL","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2010.08.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq150"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2009.12.030"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2007.26.7.931"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)04698-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2014.10.008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2011.09.003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318198a10a"}],"container-title":["International Journal of Gynecology &amp; 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