{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:39:48Z","timestamp":1793425188912,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies on the impact of adenomyosis and its pregnancy complications have yielded conflicting results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the likelihood of adverse pregnancy outcomes among women with adenomyosis relative to women without adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>PubMed, Embase, Scopus, and Web of Science were searched for studies published up to June 15, 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Observational studies with medically confirmed pregnancy outcomes as endpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Two researchers independently screened and selected relevant studies. Dichotomous data for all adverse pregnancy outcomes were expressed as an odds ratio (OR) with 95% confidence interval (CI), and combined in a meta\u2010analysis by using a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Six studies (322 cases and 9420 controls) were eligible for inclusion in the meta\u2010analysis. Women with adenomyosis had an increased likelihood of preterm birth (OR, 3.05; 95% CI, 2.08\u20134.47; <jats:italic>P<\/jats:italic>\u02c20.001), small for gestational age (OR, 3.22; 95% CI, 1.71\u20136.08; <jats:italic>P<\/jats:italic>\u02c20.001), and pre\u2010eclampsia (OR, 4.35; 95% CI, 1.07\u201317.72; <jats:italic>P<\/jats:italic>=0.042).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adenomyosis seems to have a detrimental impact on pregnancy outcomes,\u00a0resulting in a higher likelihood of preterm birth, small for gestational age, and\u00a0pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12799","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T08:38:43Z","timestamp":1551688723000},"page":"149-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Systematic review and meta\u2010analysis of adverse pregnancy outcomes after 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