{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:15:57Z","timestamp":1785831357004,"version":"3.56.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We performed a study to estimate incidence of vulvar cancer in women with vulvar symptoms (irritation, pain, bleeding +\/\u2212 presence of lesion) referred to a secondary care, rapid\u2010access clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective data collection of all direct referrals from a primary to a secondary care gynecological oncology clinic from 2011 to 2016, for women with suspicious vulvar symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>32\/393 (8.1%) women had vulvar cancer, and 24\/393 (6.1%) had a premalignant lesion. Multivariate logistic regression showed that women referred without a specific lesion had considerably lower odds of a diagnosis of vulvar cancer than those with a lesion (OR=0.11, 95% CI: 0.03\u20130.49). In total, 30\/234 (12.8%) women with a vulvar lesion (mass or ulcer), had vulvar cancer, compared with 2\/159 (1.3%) of those referred without a lesion (these patients had vulvar irritation and bleeding but had a visible lesion on examination). None of the 140 women with irritation alone, in the absence of a visible lesion or bleeding, had pre\u2010invasive disease or cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Presence of a vulvar lesion, especially if painful\/bleeding, has a high positive predictive value for vulvar cancer and 12.8% of women presenting with any vulvar lesion to secondary care had cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12818","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T12:49:27Z","timestamp":1554122967000},"page":"283-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relationship between vulvar symptoms and incidence of vulvar cancer in women referred to a rapid access clinic"],"prefix":"10.1002","volume":"145","author":[{"given":"Alison","family":"Wiggans","sequence":"first","affiliation":[{"name":"Department of Gynaecological Oncology GRACE Centre Musgrove Park Hospital  Taunton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Coleridge","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology GRACE Centre Musgrove Park Hospital  Taunton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bryant","sequence":"additional","affiliation":[{"name":"Institute of Health and Society Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology GRACE Centre Musgrove Park Hospital  Taunton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Cancer Research UK.Vulval Cancer Incidence.https:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/vulval-cancer\/incidence. 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