{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T20:59:45Z","timestamp":1694465985759},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effect of a 5\u2010hydroxytryptamine\u20103 receptor antagonist (granisetron) on the use of sympathomimetic (cafedrine\/theodrenaline) and uterotonic (oxytocin) agents after spinal anesthesia during cesarean delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective observational analysis was conducted using intraoperative records (n=240) created at a single hospital in Germany between November 1, 2016, and July 31, 2017. The granisetron group (n=120) had received 3\u00a0mg of granisetron immediately before induction of spinal anesthesia. The control group (n=120) had not received granisetron. The primary endpoints were the intraoperative requirements for sympathomimetic and uterotonic agents. The secondary endpoints were parameters of intraprocedural maternal hemodynamic and clinical states.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More patients in the granisetron group than in the control group received intraoperative cafedrine\/theodrenaline (<jats:italic>P<\/jats:italic>=0.045), with the cumulative intraoperative dosage also increased in the granisetron group (<jats:italic>P<\/jats:italic>=0.016). By contrast, the cumulative intraoperative dose of oxytocin was lower in the granisetron group than in the control group (<jats:italic>P<\/jats:italic>&lt;0.001). Decreases in heart rate and mean arterial blood pressure were lower in the granisetron group versus the control group (<jats:italic>P<\/jats:italic>=0.015 and <jats:italic>P<\/jats:italic>=0.002, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment with granisetron immediately before cesarean delivery did not reduce the perioperative requirement for sympathomimetics but did reduce the need for uterotonics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Registered at ClinicalTrials.gov (NCT03318536)<\/jats:title><\/jats:sec>","DOI":"10.1002\/ijgo.12819","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T10:53:01Z","timestamp":1554115981000},"page":"361-366","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Granisetron reduces the need for uterotonics but not sympathomimetics during cesarean delivery"],"prefix":"10.1002","volume":"145","author":[{"given":"Florian J.","family":"Raimann","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Intensive Care Medicine and Pain Therapy University Hospital Frankfurt  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrica P.","family":"Baldauf","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Intensive Care Medicine and Pain Therapy University Hospital Frankfurt  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Louwen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Frankfurt  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Jennewein","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Frankfurt  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dania","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Intensive Care Medicine and Pain Therapy University Hospital Frankfurt  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zacharowski","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Intensive Care Medicine and Pain Therapy University Hospital Frankfurt  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian F.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Intensive Care Medicine and Pain Therapy University Hospital Frankfurt  Frankfurt am Main Germany"},{"name":"Department of Anesthesiology Intensive Care Medicine and Pain Therapy Asklepios Hospital Wandsbek  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007184"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2007.11.010"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.69.351"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182312e21"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001905"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12445"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2016.11.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001974"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001846"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2014.10.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev248"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4103\/1115-2613.278300","article-title":"Crystalloid preload shows transient superiority over colloid, or their combination in spinal anaesthesia\u2010induced hypotension prophylaxis for caesarean section","volume":"24","author":"Osazuwa IH","year":"2015","journal-title":"Niger J Med"},{"key":"e_1_2_7_14_1","first-page":"1019","article-title":"Colloids versus crystalloids in the prevention of hypotension induced by spinal anesthesia in elective cesarean section. 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