{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:13:52Z","timestamp":1789906432010,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare clinical and metabolic profiles between <jats:italic>N<\/jats:italic>\u2010acetylcysteine and <jats:sc>l<\/jats:sc>\u2010carnitine among women with clomiphene citrate (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>)\u2010resistant polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized trial at Zagazig University between January 2017 and March 2018. Women with <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\u2010resistant <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> were allocated randomly to receive <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> plus <jats:italic>N<\/jats:italic>\u2010acetylcysteine or <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> plus <jats:sc>l<\/jats:sc>\u2010carnitine. The primary outcome was clinical pregnancy rate; secondary outcomes were ovulation rate and metabolic changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 162 women completed the study (<jats:italic>N<\/jats:italic>\u2010acetylcysteine group, n=82; <jats:sc>l<\/jats:sc>\u2010carnitine group, n=80). After 3\u00a0months, there was no difference in pregnancy (<jats:italic>P<\/jats:italic>=0.15), ovulation (<jats:italic>P<\/jats:italic>=0.21), or spontaneous abortion (<jats:italic>P<\/jats:italic>=0.11) rates between the two groups. There was no significant decrease in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in either group (both <jats:italic>P<\/jats:italic>&gt;0.05). There were improvements in menstrual pattern, follicle\u2010stimulating hormone, luteinizing hormone, free testosterone, and insulin resistance markers in both groups (all <jats:italic>P<\/jats:italic>&lt;0.05). An improvement in lipid profile was observed only in the <jats:sc>l<\/jats:sc>\u2010carnitine group (<jats:italic>P<\/jats:italic>&lt;0.001). <jats:italic>N<\/jats:italic>\u2010Acetylcysteine treatment led to significantly greater improvement in free testosterone and insulin resistance parameters as compared with <jats:sc>l<\/jats:sc>\u2010carnitine (all <jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both <jats:italic>N<\/jats:italic>\u2010acetylcysteine and <jats:sc>l<\/jats:sc>\u2010carnitine were equally effective in improving pregnancy and ovulation rates among women with <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\u2010resistant <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. However, <jats:italic>N<\/jats:italic>\u2010acetylcysteine was superior in ameliorating insulin resistance and only <jats:sc>l<\/jats:sc>\u2010carnitine improved lipid profile.<\/jats:p><jats:p>Trial Registration: ClinicalTrials.gov: <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>03164421.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12902","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T01:59:57Z","timestamp":1562291997000},"page":"59-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<i>Retracted:<\/i> Randomized controlled trial of <i>N<\/i>\u2010acetylcysteine versus <scp>l<\/scp>\u2010carnitine among women with clomiphene\u2010citrate\u2010resistant polycystic ovary syndrome"],"prefix":"10.1002","volume":"147","author":[{"given":"Ibrahim A.","family":"El Sharkwy","sequence":"first","affiliation":[{"name":"Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walled M.","family":"Abd El Aziz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.12891\/ceog16222014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1117069"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3918"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD14182"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2012.01844.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13003"},{"issue":"19","key":"e_1_2_7_8_1","first-page":"41","article-title":"Revised consensus on diagnostic criteria and long\u2010term health risks related to polycystic ovary syndrome (PCOS)","volume":"2004","author":"Rotterdam ESHRE\/ASRM\u2010Sponsored PCOS Consensus Workshop Group","year":"2003","journal-title":"Hum Reprod"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2009.1920"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/817849"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2009.12.012"},{"key":"e_1_2_7_12_1","first-page":"1","article-title":"The adjuvant effect of metformin and N\u2010acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome","volume":"4","author":"Maged AM","year":"2015","journal-title":"Gynecol Endocrinol"},{"key":"e_1_2_7_13_1","first-page":"1","article-title":"Antioxidantsand management of polycystic ovary syndrome in Iran: A systematic review of clinical trials","volume":"13","author":"Amini L","year":"2015","journal-title":"Iran J Reprod Med"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.29252\/ijrm.15.4.203"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20174407"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20172938"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.173"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1115974"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.06.008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2016.1264375"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.10.017"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1290071"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.153767"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000151488"},{"key":"e_1_2_7_25_1","first-page":"510483","article-title":"Effects of oral l\u2010carnitine supplementation on lipid profile, anemia, and quality of life in chronic renal disease patients under hemodialysis: A randomized, double\u2010blinded, placebo\u2010controlled trial","author":"Emami Naini A","year":"2012","journal-title":"J Nutr Metab"}],"updated-by":[{"DOI":"10.1002\/ijgo.14995","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"record-id":"46081"},{"DOI":"10.1002\/ijgo.14995","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000}}],"container-title":["International Journal of Gynecology &amp; 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