{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:19:19Z","timestamp":1758820759664},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2019,10]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To evaluate the spontaneous progression of cervical intraepithelial neoplasia grade 2 (CIN<\/jats:styled-content>2) in accordance with Chlamydia trachomatis<\/jats:italic> (chlamydia) serology.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective observational study included women diagnosed with CIN<\/jats:styled-content>2 by cervical biopsy and managed conservatively for 24\u00a0months at Hospital del Mar, Barcelona, between December 2011 and October 2013. Serum anti\u2010chlamydia immunoglobulin G (IgG), previous cytology, and high\u2010risk human papillomavirus (HPV<\/jats:styled-content>) genotyping were recorded at baseline. The outcome was regression, persistence, or progression of CIN<\/jats:styled-content>2.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, 93 women aged 18\u201356\u00a0years were enrolled. Spontaneous regression was observed for 61 (66%) women, and 21 (23%) progressed to CIN<\/jats:styled-content>3. Eight (9%) women had chlamydia seropositivity at baseline. Multivariate analysis showed that anti\u2010chlamydia IgG seropositivity (odds ratio [OR<\/jats:styled-content>], 19.1; 95% confidence interval [CI<\/jats:styled-content>], 1.9\u2013189.7), previous high\u2010grade squamous intraepithelial lesion cytology (OR<\/jats:styled-content>, 5.0; 95% CI<\/jats:styled-content>, 1.7\u201314.6), and HPV<\/jats:styled-content>16 (OR<\/jats:styled-content>, 4.8; 95% CI<\/jats:styled-content>, 1.7\u201313.7) increased the risk of CIN<\/jats:styled-content>2 persistence or progression.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Women with CIN<\/jats:styled-content>2 and chlamydia IgG seropositivity had increased risk of progression to CIN<\/jats:styled-content>2+ and immediate treatment may be recommended for these women. Larger clinical studies are needed to confirm the results, but chlamydia serology might be introduced into CIN<\/jats:styled-content>2 management to better individualize treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12903","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T21:03:46Z","timestamp":1562274226000},"page":"43-48","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of Chlamydia trachomatis<\/i> serology in conservative management of cervical intraepithelial neoplasia grade 2"],"prefix":"10.1002","volume":"147","author":[{"given":"Ester","family":"Miralpeix","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hospital del Mar Universitat Aut\u00f2noma de Barcelona Barcelona 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