{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:18:49Z","timestamp":1763727529136},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence of anal <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotypes and associated factors in women with pre\u2010malignant lesion or cancer in the cervix and anal canal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, cross\u2010sectional study analyzed <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> samples taken from women with cervical pre\u2010malignant lesions or cancer to identify anal <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> by polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>). The prevalence of high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) in women with intraepithelial neoplasia and anal cancer was calculated; sociodemographic and clinical risk factors were identified using multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 152 patients were included (mean age 37.8\u00a0\u00b1\u00a010.01\u00a0years), of whom 101 (66.4%) had anal <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>. Fourteen different anal <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types were identified. <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> 16 and 18 were found in 30 (52.6%) anal high\u2010grade squamous intraepithelial lesions (<jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>), and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> 31 and 33 in 21 (36.8%) lesions. In the logistic regression analysis, the factors that remained associated with <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types were: an anal histopathology report of <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content> or invasive carcinoma (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 8.96, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 3.40\u201323.57; <jats:italic>P<\/jats:italic>&lt;0.0001) and alcohol consumption (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.20, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.01\u20134.80; <jats:italic>P<\/jats:italic>=0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prevalence of <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> is high in the anal canal of women with cervical and anal pre\u2010malignant lesions simultaneously or cancer of the cervix and\/or anal canal. <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> 16, 31, 33, and 18 were the four major genotypes identified.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12933","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T03:00:28Z","timestamp":1564369228000},"page":"225-232","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anal prevalence of <scp>HPV<\/scp> in women with pre\u2010malignant lesion or cancer in the cervix and anal canal simultaneously: cross\u2010sectional study"],"prefix":"10.1002","volume":"147","author":[{"given":"Sandra A.","family":"Her\u00e1clio","sequence":"first","affiliation":[{"name":"Department of Lower Genital Tract Pathology Instituto de Medicina Integral Professor Fernando Figueira (IMIP)  Recife PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex S.R.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine and Ultrasonography Instituto de Medicina Integral Professor Fernando Figueira (IMIP)  Recife PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel K.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Coloproctology Instituto de Medicina Integral Professor Fernando Figueira (IMIP)  Recife PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leuridan C.","family":"Torres","sequence":"additional","affiliation":[{"name":"Translational Health Research Laboratory Instituto de Medicina Integral Professor Fernando Figueira (IMIP)  Recife PE 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