{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:04:44Z","timestamp":1767135884859,"version":"build-2238731810"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2019,11]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n To investigate the characteristics of women developing cervical intraepithelial neoplasia who had had a vaccination against human papillomavirus (\n HPV<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A retrospective cohort study was carried out of women diagnosed with moderate or severe cervical dysplasia (\n CIN<\/jats:styled-content>\n 2+) in four Italian centers between 2015 and\u00a02017. All women included had had previous bivalent or quadrivalent vaccination against\n HPV<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The present study included 43 patients affected by\n CIN<\/jats:styled-content>\n 2+. The median age was 28 (range, 21\u201341) years. Ten (23.3%) patients did not have a diagnosis of specific\n HPV<\/jats:styled-content>\n type(s) involved: high\u2010risk\n HPV<\/jats:styled-content>\n was detected in 7 (16.3%) women while\n HPV<\/jats:styled-content>\n testing was negative in 3 (6.9%) women. Lesions related to\n HPV<\/jats:styled-content>\n 16 were found in two patients.\n HPV<\/jats:styled-content>\n types covered by nonavalent vaccination were diagnosed in 27\/33 (81.8%) women.\n HPV<\/jats:styled-content>\n types not covered by nonavalent vaccination were diagnosed in 6 (18.2%) women. Co\u2010infections are most commonly detected in women with\n HPV<\/jats:styled-content>\n s other than those included in the nonavalent vaccination (\n P<\/jats:italic>\n =0.024).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Cervical dysplasia occurring after\n HPV<\/jats:styled-content>\n vaccination is a rare condition. Theoretically, nonavalent vaccination should improve protection against more than 80% of\n HPV<\/jats:styled-content>\n \u2010related lesions compared to other vaccines.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.12934","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T14:54:40Z","timestamp":1564498480000},"page":"233-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cervical intraepithelial neoplasia in women who had vaccination against\n HPV<\/scp>"],"prefix":"10.1002","volume":"147","author":[{"given":"Giorgio","family":"Bogani","sequence":"first","affiliation":[{"name":"Gynecologic Oncology IRCCS National Cancer Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Serati","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Ospedale di Circolo Fondazione Macchi University of Insubria Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Leone Roberti Maggiore","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology IRCCS National Cancer Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Ditto","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology IRCCS National Cancer Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Gardella","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology IRCCS Fondazione Policlinico San Matteo University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Academic Unit of Obstetrics and Gynaecology IRCCS Ospedale Policlinico San Martino Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) University of Genoa Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arsenio","family":"Spinillo","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology IRCCS Fondazione Policlinico San Matteo University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Ospedale di Circolo Fondazione Macchi University of Insubria Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Raspagliesi","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology IRCCS National Cancer Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e318286bb53"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70086-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31883"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn036"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118756747"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.12.017"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12546"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000432"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12170"},{"key":"e_1_2_7_11_1","volume-title":"Cervix cancer screening\/IARC handbooks of cancer prevention. 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