{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:59:58Z","timestamp":1775149198112,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009568","name":"Universidade Estadual Paulista","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009568","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate calcium metabolism and bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) in new users of depot medroxyprogesterone acetate (<jats:styled-content style=\"fixed-case\">DMPA<\/jats:styled-content>) in the first year of use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, non\u2010randomized study, conducted at the University of Campinas, S\u00e3o Paulo, Brazil, was carried out between February 2011 and February 2013. Women aged from 18 to 40 with a body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, calculated as weight in kilograms divided by the square of height in meters) &lt;30 and with no known history of disease or medication use who chose to use <jats:styled-content style=\"fixed-case\">DMPA<\/jats:styled-content> were paired by age (\u00b11\u00a0year) and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (\u00b11) with women commencing the use of a copper intrauterine device (<jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content>). The primary outcomes were <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> measured by dual\u2010energy X\u2010ray absorptiometry and calcium metabolism markers; other variables were body composition and lifestyle habits. Repeated measures analysis of variance (<jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content>) and multiple regression analyses were used to evaluate associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven women using <jats:styled-content style=\"fixed-case\">DMPA<\/jats:styled-content> and 24 using <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> were evaluated, with a mean age of 29.7\u00a0years and 28.6\u00a0years, respectively. The <jats:styled-content style=\"fixed-case\">DMPA<\/jats:styled-content> group presented with a 3.6% (<jats:italic>P<\/jats:italic>&lt;0.001) loss of lumbar spine <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>, a 2.1% (<jats:italic>P<\/jats:italic>=0.100) loss of femoral neck <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> and higher phosphorus (<jats:italic>P<\/jats:italic>=0.014) concentrations at 12\u00a0months compared to the <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> group. The decreases in <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> were associated with the use of <jats:styled-content style=\"fixed-case\">DMPA<\/jats:styled-content>, while total mass and coffee intake were found to be protective factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Changes in calcium metabolism and a decrease in <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> were found in the <jats:styled-content style=\"fixed-case\">DMPA<\/jats:styled-content> group at 12\u00a0months.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12958","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T18:46:48Z","timestamp":1567536408000},"page":"319-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Changes in calcium metabolism and bone mineral density in new users of medroxyprogesterone acetate during the first year of use"],"prefix":"10.1002","volume":"147","author":[{"given":"Alessandra","family":"Quintino\u2010Moro","sequence":"first","affiliation":[{"name":"Family Planning Clinic Department of Obstetrics and Gynecology School of Medical Sciences University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise E.","family":"Zantut\u2010Wittmann","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine School of Medical Sciences University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla N.","family":"Silva dos Santos","sequence":"additional","affiliation":[{"name":"Family Planning Clinic Department of Obstetrics and Gynecology School of Medical Sciences University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concei\u00e7\u00e3o A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine School of Medical Sciences University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Bahamondes","sequence":"additional","affiliation":[{"name":"Family Planning Clinic Department of Obstetrics and Gynecology School of Medical Sciences University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arlete","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Family Planning Clinic Department of Obstetrics and Gynecology School of Medical Sciences University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Quintino\u2010MoroA.Evaluation of thyroid hormone bone mineral density and calcium metabolism in new users of the contraceptive depot medroxyprogesterone acetate during the first year of use of the method\u2019.http:\/\/repos\u200bitorio.unica\u200bmp.br\/jspui\/\u200bbitst\u200bream\/REPOS\u200bIP\/33390\u200b5\/1\/Quint\u200bino-Moro_Aless\u200bandra_D.pdf. 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