{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:01:03Z","timestamp":1791414063687,"version":"4.3.3"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003358","name":"Gedeon Richter","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003358","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To observe alterations in surgical planning that were due to the use of ulipristal acetate (<jats:styled-content style=\"fixed-case\">UPA<\/jats:styled-content>) 5\u00a0mg daily for symptomatic uterine fibroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort trial involving women with symptomatic fibroids was undertaken in 23 clinical practice sites within Belgium between October 1, 2014, and March 31, 2016, to compare initial surgical planning to performed surgical procedures following the use of <jats:styled-content style=\"fixed-case\">UPA<\/jats:styled-content> 5\u00a0mg daily for 3\u00a0months. Secondary outcomes were surgical complications, reduction in fibroids, bleeding control, and adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and twenty\u2010two women were recruited for the trial. The requirement for surgery decreased with the use of <jats:styled-content style=\"fixed-case\">UPA<\/jats:styled-content>, with 54% of women undergoing surgery after treatment. The reduction in surgery performed was lower for women willing to conceive (40%) compared to women who were not (49%). The volume of the fibroids decreased significantly, with the largest measured fibroid decreasing by 50%. Bleeding and pain were significantly decreased with the use of <jats:styled-content style=\"fixed-case\">UPA<\/jats:styled-content>. No major complications were recorded, and no liver function abnormalities were reported during the treatment and in follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>By administering <jats:styled-content style=\"fixed-case\">UPA<\/jats:styled-content>, the required rate of surgery was significantly decreased. Also, the resulting reduction in size of the fibroids could have the potential benefit of reducing surgery\u2010related complications, and long\u2010term use may be warranted to avoid surgery completely.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12968","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T10:55:13Z","timestamp":1568112913000},"page":"339-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect on surgical decisions: Ulipristal acetate as key player in Belgian phase <scp>IV<\/scp> registration trial"],"prefix":"10.1002","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2185-1213","authenticated-orcid":false,"given":"Jasper","family":"Verguts","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Jessa Hospital  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre Arnaud","family":"Godin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology CHC  Rocourt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"De Vree","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology ZNA Middelheim  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Donnez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology ICA Polyclinique Urbain V  Avignon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Cosyns","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology UZ Brussel  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Luyckx","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology UCL Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Nisolle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology CHR de la Citadelle  Liege Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000136079.62513.39"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4293\/JSLS.2017.00041"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4697-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10397-016-0960-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10397-017-1025-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2017.01.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103182"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103180"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.02.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.09.032"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.11.003"}],"container-title":["International Journal of Gynecology &amp; 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