{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:06:52Z","timestamp":1773284812678,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T00:00:00Z","timestamp":1571443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the safety and efficacy of flushing the cervical canal and the uterine cavity with local anesthetic in order to reduce the pain felt by patients during office hysteroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A double\u2010blind randomized controlled trial was conducted between May 1, 2018, and February 28, 2019, involving 260 women undergoing office hysteroscopy at Kasr Al Ainy Hospital, Cairo, Egypt. Women were randomized using a computerized random number generator to intrauterine and intracervical instillation 5\u00a0minutes before the procedure of either 5\u00a0mL lidocaine 2% diluted in 15\u00a0mL normal saline, or 20\u00a0mL normal saline alone. The primary outcome measure was the visual analog scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) pain score reported by women during the procedure. Secondary outcomes included <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> score at 10 and 30\u00a0minutes after the procedure, the need for analgesia, and occurrence of vasovagal attacks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women in the lidocaine flushing group reported a significantly lower <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> score during the procedure (1.8\u00a0\u00b1\u00a01.1 vs 5.2\u00a0\u00b1\u00a01.8) and 10 and 30\u00a0minutes after it (1.3\u00a0\u00b1\u00a01.15 and 0.8\u00a0\u00b1\u00a00.9 vs 4.3\u00a0\u00b1\u00a02.1 and 2.98\u00a0\u00b1\u00a01.96) when compared with control women (<jats:italic>P<\/jats:italic>&lt;0.001). More women without lidocaine flushing experienced vasovagal attacks (25\/130 vs 9\/130, <jats:italic>P<\/jats:italic>&lt;0.001) and needed analgesia (84\/130 vs 13\/130, <jats:italic>P<\/jats:italic>&lt;0.001) when compared with women with lidocaine flushing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Flushing of the cervical canal and uterine cavity with local anesthetic significantly decreased pain sensation in women undergoing office hysteroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>ClinicalTrials.gov: NCT03530488<\/jats:title><\/jats:sec>","DOI":"10.1002\/ijgo.12992","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T15:00:40Z","timestamp":1570546840000},"page":"113-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["RETRACTED: The value of endocervical and endometrial lidocaine flushing before office hysteroscopy: A randomized controlled trial"],"prefix":"10.1002","volume":"148","author":[{"given":"Amira Y.","family":"Shoab","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kasr Al Ainy Cairo University \u2013 Faculty of Medicine  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Maged","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kasr Al Ainy Cairo University \u2013 Faculty of Medicine  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafaa","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kasr Al Ainy Cairo University \u2013 Faculty of Medicine  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif","family":"Dahab","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kasr Al Ainy Cairo University \u2013 Faculty of Medicine  Cairo 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