{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:23:07Z","timestamp":1790893387736,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the risk of adverse fetal outcomes after exposure to oral antifungal agents during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>PubMed, Embase, and Cochrane Central Register of Controlled Trials (<jats:styled-content style=\"fixed-case\">CENTRAL<\/jats:styled-content>) were searched up to October 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Cohort studies and case\u2013control studies investigating fetal outcomes following maternal exposure to oral antifungal agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Two reviewers independently assessed studies for inclusion, assessed risk of bias, and extracted data. Pooled estimates were calculated for the frequency of adverse fetal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Overall, eight cohort studies and one case\u2013control study were included. The oral antifungal agents used during pregnancy were fluconazole and itraconazole. The data indicated that oral fluconazole exposure during pregnancy might slightly increase the risk of congenital heart defects and limb defects relative to the general population; oral itraconazole during pregnancy might increase the risk of eye defects. No difference was found between oral fluconazole\/itraconazole exposure and non\u2010exposure in the risk of other birth defects, spontaneous abortion, or stillbirth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral fluconazole or itraconazole may not increase the risk of birth defects. Nonetheless, the risk of congenital heart defects and limb defects after fluconazole exposure and eye defects after itraconazole exposure should be cautiously investigated.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12993","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T04:01:13Z","timestamp":1573012873000},"page":"6-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Fetal outcomes after maternal exposure to oral antifungal agents during pregnancy: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"148","author":[{"given":"Dan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacy\/Evidence\u2010Based Pharmacy Center West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Dis\u2010eases of Women and Children Ministry of Education Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy\/Evidence\u2010Based Pharmacy Center West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Dis\u2010eases of Women and Children Ministry of Education Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Dis\u2010eases of Women and Children Ministry of Education Sichuan University  Chengdu China"},{"name":"Department of Obstetrics and Gynecology West China Second University Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Dis\u2010eases of Women and Children Ministry of Education Sichuan University  Chengdu China"},{"name":"Department of Obstetrics and Gynecology West China Second University Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Dis\u2010eases of Women and Children Ministry of Education Sichuan University  Chengdu China"},{"name":"Department of Obstetrics and Gynecology West China Second University Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462418785451"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60917-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.2.336"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19971031)72:3<253::AID-AJMG1>3.0.CO;2-S"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20189"},{"key":"e_1_2_9_7_1","unstructured":"WellsGASB O'ConnellD PetersonJ et\u00a0al.The Newcastle\u2010Ottawa scale (NOS) for assessing the quality of non\u2010randomized studies in meta\u2010analysis.http:\/\/www.ohri.ca\/progr\u200bams\/clini\u200bcal_epide\u200bmiolo\u200bgy\/oxford.asp. 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