{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T04:18:41Z","timestamp":1729916321422,"version":"3.28.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the placental staining pattern of fibronectin, an extracellular matrix protein essential for trophoblastic invasion, in pre\u2010eclampsia and fetal growth restriction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study conducted at the University of Udine, including the placentas of women with pre\u2010eclampsia and fetal growth restriction collected between January 1, 2001, and December 31, 2010. Fibronectin was evaluated in placental tissue micro\u2010array by immunohistochemistry, describing localization and intensity of staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included the placentas of 36 women with early\u2010onset (delivery &lt;34\u00a0weeks of gestation) pre\u2010eclampsia; 6 with early\u2010onset <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome; 17 with early\u2010onset intrauterine growth restriction (<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>); 14 with late\u2010onset (delivery \u226534\u00a0weeks of gestation) pre\u2010eclampsia; 35 with late\u2010onset <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>; 18 with small for gestational age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) fetuses (birth weight &lt;10th percentile); and 64 controls. Fibronectin was present both at the cell surface and in the cytoplasm. Cytoplasm staining intensity resulted higher in early forms of pregnancy\u2010related complications compared to controls, although this was statistically significant (<jats:italic>P<\/jats:italic>&lt;0.05) only for early\u2010onset pre\u2010eclampsia (<jats:italic>P<\/jats:italic>=0.085 for <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome; <jats:italic>P<\/jats:italic>=0.091 for <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>). Also, late\u2010onset forms of pre\u2010eclampsia had stronger cytoplasmic and pericellular staining compared to controls (<jats:italic>P<\/jats:italic>&lt;0.05). Interestingly, staining of both late\u2010onset <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> was comparable to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fibronectin appeared to be unaffected in women with late\u2010onset <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> fetuses, suggesting a peculiar common pathogenetic pattern in these conditions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13060","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T19:22:05Z","timestamp":1574191325000},"page":"253-260","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Placental fibronectin staining is unaffected in pregnancies complicated by late\u2010onset intrauterine growth restriction and small for gestational age fetuses"],"prefix":"10.1002","volume":"148","author":[{"given":"Arrigo","family":"Fruscalzo","sequence":"first","affiliation":[{"name":"Clinic of Obstetrics and Gynecology Christophorus\u2010Kliniken  Coesfeld Germany"},{"name":"Clinic of Obstetrics and Gynecology University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambrogio P.","family":"Londero","sequence":"additional","affiliation":[{"name":"Clinic of Obstetrics and Gynecology DAME University of Udine  Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Orsaria","sequence":"additional","affiliation":[{"name":"Institute of Pathology DAME University of Udine  Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Marzinotto","sequence":"additional","affiliation":[{"name":"Institute of Pathology DAME University of Udine  Udine 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