{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:43:48Z","timestamp":1768869828109,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effectiveness of an oral versus sublingual loading dose of nifedipine for tocolysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An open, randomized clinical trial conducted between March 1, 2013, and April 31, 2014. Participants were pregnant women with a diagnosis of premature labor, single live fetus, topical pregnancy, gestational age 24\u201336\u00a0weeks, normal fetal vitality, cervical dilatation less than or equal to 4\u00a0cm, cervical effacement less than or equal to 80%, and intact amniotic membranes. They were randomized into two groups, oral and sublingual nifedipine, 20\u00a0mg loading dose, repeated every 30\u00a0minutes (maximum dose of 60\u00a0mg). The primary endpoint was the time until tocolysis and the secondary endpoints were the effectiveness of tocolysis within 90\u00a0minutes, 12\u00a0hours, and 48\u00a0hours; premature delivery within 48\u00a0hours; and maternal hemodynamic parameters and side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 80 patients randomized to oral (n=40) and sublingual (n=40) nifedipine. The time required for tocolysis was significantly less with sublingual nifedipine (160\u00a0minutes vs 340\u00a0minutes; <jats:italic>P<\/jats:italic>=0.0003). Sublingual nifedipine was also more successful than oral nifedipine at inhibiting premature labor within 90\u00a0minutes (n=8 [20.0%] vs n=1 [2.5%], <jats:italic>P<\/jats:italic>=0.014). There was no statistically significant difference between the groups for the other secondary endpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with oral administration, a sublingual loading dose of nifedipine resulted in faster tocolysis in patients with premature labor.<\/jats:p><jats:p>Brazilian Clinical Trials Registry (ReBEC): U1111\u201011566186.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13067","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T15:54:43Z","timestamp":1574870083000},"page":"310-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effectiveness of an oral versus sublingual loading dose of nifedipine for tocolysis"],"prefix":"10.1002","volume":"148","author":[{"given":"Carlos C.","family":"Leal\u2010J\u00fanior","sequence":"first","affiliation":[{"name":"Women's Healthcare Center Instituto de Medicina Integral Prof. Fernando Figueira (IMIP)  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melania M.R.","family":"Amorim","sequence":"additional","affiliation":[{"name":"Women's Healthcare Center Instituto de Medicina Integral Prof. Fernando Figueira (IMIP)  Recife Pernambuco Brazil"},{"name":"Department of Obstetrics and Gynecology Federal University of Campina Grande (UFCG)  Campina Grande Para\u00edba Brazil"},{"name":"Department of Obstetrics Elp\u00eddio de Almeida Health Institute (ISEA)  Campina Grande Para\u00edba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo F.A.","family":"Souza","sequence":"additional","affiliation":[{"name":"Biological Sciences and Health Center Catholic University of Pernambuco (UNICAP)  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna K.S.","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Healthcare Federal University of Pernambuco (UFPE)  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex S.R.","family":"Souza","sequence":"additional","affiliation":[{"name":"Women's Healthcare Center Instituto de Medicina Integral Prof. Fernando Figueira (IMIP)  Recife Pernambuco Brazil"},{"name":"Biological Sciences and Health Center Catholic University of Pernambuco (UNICAP)  Recife Pernambuco Brazil"},{"name":"Department of Maternal and Child Healthcare Federal University of Pernambuco (UFPE)  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S1"},{"key":"e_1_2_8_3_1","unstructured":"Brazilian Ministry of Health.DATASUS\/SINASC. [Live birth registry].http:\/\/www2.datas\u200bus.gov.br\/DATAS\u200bUS\/index.php?area=060702. Accessed December 20 2018."},{"issue":"1","key":"e_1_2_8_4_1","first-page":"46","article-title":"Leading causes of child mortality in Brazil, in 1990 and 2015: Estimates from the Global Burden of Disease study","volume":"20","author":"Fran\u00e7a EB","year":"2017","journal-title":"Rev Bras Epidemiol"},{"issue":"5","key":"e_1_2_8_5_1","first-page":"CD007873","article-title":"Cervical pessary for preventing preterm birth","author":"Abdel\u2010Aleem H","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"e_1_2_8_6_1","first-page":"CD004947","article-title":"Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth","author":"Dodd JM","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2017.08.008"},{"issue":"6","key":"e_1_2_8_8_1","first-page":"CD002255","article-title":"Calcium channel blockers for inhibiting preterm labour and birth","author":"Flenady V","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"e_1_2_8_9_1","first-page":"CD003935","article-title":"Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes","author":"Crowther CA","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_10_1","first-page":"351","article-title":"Nifedipine antihypertensive treatment effects in pre\u2010eclampsia","volume":"21","author":"Souza AR","year":"2008","journal-title":"Acta Med Port"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/0144361031000153666"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v25.i5.20"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212233072605"},{"issue":"6","key":"e_1_2_8_14_1","first-page":"CD008981","article-title":"Transplacental versus direct fetal corticosteroid treatment for accelerating fetal lung maturation where there is a risk of preterm birth","author":"Utama DP","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmed-2017-110742"},{"issue":"1","key":"e_1_2_8_16_1","first-page":"CD004661","article-title":"Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus","author":"Doyle LW","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"e_1_2_8_17_1","first-page":"CD007467","article-title":"Intrapartum antibiotics for known maternal group B streptococcal colonization","author":"Ohlsson A","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-9-38"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/10903127.2014.942475"},{"key":"e_1_2_8_20_1","first-page":"552","article-title":"Transdermal nitroglycerin versus oral nifedipine administration for tocolysis: A randomized clinical trial","volume":"31","author":"Amorim MM","year":"2009","journal-title":"Rev Bras Ginecol Obstet"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00548-1"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.16.6.843"},{"issue":"6","key":"e_1_2_8_23_1","first-page":"CD004452","article-title":"Oxytocin receptor antagonists for inhibiting preterm labour","author":"Flenady V","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"e_1_2_8_24_1","first-page":"CD004352","article-title":"Betamimetics for inhibiting preterm labour","author":"Neilson JP","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_25_1","first-page":"491","article-title":"Hemodynamics effects of nifedipine as a tocolytic agent in preterm labour","volume":"36","author":"Souza AS","year":"2008","journal-title":"Femina"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2728"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.13067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T19:18:37Z","timestamp":1694114317000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.13067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,11]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/ijgo.13067"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.13067","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,11]]},"assertion":[{"value":"2019-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}