{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:05:21Z","timestamp":1762999521505},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T00:00:00Z","timestamp":1576540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2020,3]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To assess the effects of the levonorgestrel\u2010releasing intrauterine system (LNG<\/jats:styled-content>\u2010IUS<\/jats:styled-content>) on standard cardiovascular risk markers among women with thrombophilia and\/or previous venous thromboembolism (VTE<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective cohort study enrolled women aged 18\u201345\u00a0years with thrombophilia and\/or a history of VTE<\/jats:styled-content> who received the 52\u2010mg LNG<\/jats:styled-content>\u2010IUS<\/jats:styled-content> (20\u00a0\u03bcg\/d initial release) at the University of Ribeir\u00e3o Preto Medical School, Brazil, from January 2006 to December 2015. Before and 12\u00a0months after LNG<\/jats:styled-content>\u2010IUS<\/jats:styled-content> placement, the following cardiovascular risk markers were assessed: lipid profile, body mass index (BMI<\/jats:styled-content>), blood glucose, systolic blood pressure, diastolic blood pressure, and waist circumference. The primary outcome was changes in cardiovascular risk markers. A subanalysis of anticoagulant users versus non\u2010users was also conducted.<\/jats:p><\/jats:sec>Results<\/jats:title>In total, 45 women were enrolled. BMI<\/jats:styled-content> increased by 2.3% after 12\u00a0months of LNG<\/jats:styled-content>\u2010IUS<\/jats:styled-content> placement (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01), but the other risk factors did not change. Cardiovascular risk markers were similar between anticoagulant users and non\u2010users after 12\u00a0months of LNG<\/jats:styled-content>\u2010IUS<\/jats:styled-content> use.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Among women with thrombophilia and\/or previous VTE<\/jats:styled-content>, cardiovascular risk markers were not found to change significantly after 12\u00a0months of LNG<\/jats:styled-content>\u2010IUS<\/jats:styled-content> use. The study adds safety information regarding use of the LNG<\/jats:styled-content>\u2010IUS<\/jats:styled-content> for women at risk of thromboembolism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13070","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T16:24:17Z","timestamp":1574958257000},"page":"381-385","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of the levonorgestrel\u2010releasing intrauterine system on cardiovascular risk markers among women with thrombophilia or previous venous thromboembolism"],"prefix":"10.1002","volume":"148","author":[{"given":"Giordana C.","family":"Braga","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Medical School of Ribeirao Preto University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena 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