{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T08:55:06Z","timestamp":1764060906811},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the relationship between large loop excision of the transformation zone (LLETZ) depth and the persistence of disease and human papillomavirus (HPV) infection in patients with cervical intraepithelial neoplasia grades 2 and 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional observational retrospective study included women with cervical intraepithelial neoplasia grades 2 and 3 who underwent LLETZ at Hospital Universitario Santa Luc\u00eda, Cartagena, Spain, from November 1, 2011, to December 31, 2016. Follow\u2010up of cytology and HPV detection were performed at 6 and 12\u201318\u00a0months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study of 256 women, multivariate analysis revealed that conization depth of 10\u00a0mm or less did not indicate an increase of persistence\/recurrence of pathological cytology at 6\u00a0months (<jats:italic>P<\/jats:italic>=0.094) and after 12\u201318\u00a0months (<jats:italic>P<\/jats:italic>=0.234), or infection by HPV at 6\u00a0months (<jats:italic>P<\/jats:italic>=0.675) and 12\u201318\u00a0months (<jats:italic>P<\/jats:italic>=0.938) after LLETZ. The affected endocervical margin at 6\u00a0months is the sole independent risk factor for persistence, both in the lesion (<jats:italic>P<\/jats:italic>=0.003) and HPV (<jats:italic>P<\/jats:italic>=0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Conization depth lower than 10\u00a0mm at LLETZ did not increase disease persistence or infection by HPV in an 18\u00a0month monitoring period. Therefore, higher depth conizations would not be justified to ensure favorable oncological results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13080","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T06:16:03Z","timestamp":1575872163000},"page":"316-324","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Does the trend toward less deep excisions in LLETZ to minimize obstetric risk lead to less favorable oncological outcomes?"],"prefix":"10.1002","volume":"148","author":[{"given":"Rosario","family":"Lara\u2010Pe\u00f1aranda","sequence":"first","affiliation":[{"name":"Deptartment of Medicine Faculty of Health Sciences Universidad Cat\u00f3lica San Antonio de Murcia (UCAM)  Murcia Spain"},{"name":"Department of Obstetrics and Gynecology Hospital Universitario Santa Luc\u00eda  Cartagena Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar 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