{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:43:24Z","timestamp":1788327804424,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effectiveness of a 12\u2010hour versus 24\u2010hour intravenous maintenance dose of magnesium sulfate (Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub>) in women with pre\u2010eclampsia, and the maternal and fetal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized controlled trial conducted at the labor ward complex of University College Hospital, Ibadan, Nigeria between May and August 2014. Pregnant women with severe pre\u2010eclampsia were randomized to receive a 12\u2010hour versus 24\u2010hour maintenance dose of Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub>. Study outcomes were occurrence of seizures, adverse maternal effects, neonatal survival, and admission to the intensive care unit. Data analysis involved descriptive statistics and bivariate analysis using Statistical Package for Social Science (<jats:styled-content style=\"fixed-case\">SPSS<\/jats:styled-content>) version 20.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 80 patients randomized to the 12\u2010hour (n=40) and 24\u2010hour (n=40) groups. The participants in the two groups had comparable demographic features. There was no significant difference (<jats:italic>P<\/jats:italic>&gt;0.999) between the satisfactory maternal outcome following the 12\u2010hour maintenance dose and the standard 24\u2010hour regimen (95.0% vs 97.5%). Similarly, there was no significant difference (<jats:italic>P<\/jats:italic>=0.276) in perinatal mortality in the 12\u2010hour versus 24\u2010hour arm (17.5% vs 12.5%, respectively). No case of eclampsia and maternal death was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A 12\u2010hour maintenance dose of intravenous Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub> in the management of severe pre\u2010eclampsia is effective and safe when compared with the 24\u2010hour maintenance dose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13082","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T04:40:08Z","timestamp":1576212008000},"page":"37-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Intravenous magnesium sulfate in the management of severe pre\u2010eclampsia: A randomized study of 12\u2010hour versus 24\u2010hour maintenance dose"],"prefix":"10.1002","volume":"149","author":[{"given":"Emmanuel A.","family":"Unwaha","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Ibadan\/University College Hospital  Ibadan Oyo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folasade A.","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Ibadan\/University College Hospital  Ibadan Oyo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwasomidoyin O.","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Ibadan\/University College Hospital  Ibadan Oyo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adesina","family":"Oladokun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Ibadan\/University College Hospital  Ibadan Oyo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2011.09.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/1119-3077.91747"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.02.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6909.2010.01172.x"},{"key":"e_1_2_7_7_1","unstructured":"World Health Organization.WHO recommendations for prevention and treatment of pre\u2010eclampsia and eclampsia. Published2011.https\u200b:\/\/apps.who.int\/iris\/bitst\u200bream\/10665\/\u200b44703\/\u200b1\/97892\u200b41548\u200b335_eng.pdf. Accessed August 13 2018."},{"key":"e_1_2_7_8_1","first-page":"661","article-title":"Risk factors of pre\u2010eclampsia in Thai women","volume":"93","author":"Luealon P","year":"2010","journal-title":"J\u00a0Med Assoc Thai"},{"issue":"10","key":"e_1_2_7_9_1","first-page":"CD000025","article-title":"Magnesium sulphate and other anticonvulsants for women with pre\u2010eclampsia","author":"Duley L","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-195"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90538-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(78)90816-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.01.029"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2004.06.019"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-2-165"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161-0932.1000447"},{"key":"e_1_2_7_17_1","first-page":"395","article-title":"Magnesium sulfate maintenance infusion in women with preeclampsia: A randomized comparison between 2 gram per hour and 1 gram per hour","volume":"96","author":"Charoenvidhya D","year":"2013","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1424-3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.15406\/ogij.2015.02.00059"},{"key":"e_1_2_7_20_1","first-page":"QC08","article-title":"Single loading low dose MgSO4 regimen: A simple, safe and effective alternative to Pritchard's regimen for Indian women","volume":"11","author":"Nagaria T","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13424"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijgo.13082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.13082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T16:40:58Z","timestamp":1693154458000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.13082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,8]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/ijgo.13082"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.13082","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,8]]},"assertion":[{"value":"2019-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}