{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T17:09:22Z","timestamp":1781975362165,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the efficacy and safety of outpatient administration of oral hyoscine for cervical ripening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a randomized controlled trial at a university hospital in Tehran between September 2017 and December 2018, 100 primiparous women with singleton pregnancy at 38<jats:sup>0<\/jats:sup>\u201340<jats:sup>0<\/jats:sup> gestational weeks and Bishop score of 5 or less were randomized to either routine expectant management (control group) or 10\u00a0mg of oral hyoscine twice daily for 1\u00a0week, followed by once daily for 1\u00a0week (hyoscine group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> Bishop score in the hyoscine and control groups was, respectively, 1.19\u00a0\u00b1\u00a01.38 and 1.08\u00a0\u00b1\u00a01.70 at baseline, and 4.56\u00a0\u00b1\u00a02.87 and 2.76\u00a0\u00b1\u00a02.14 on admission for delivery (<jats:italic>P<\/jats:italic>=0.001). Duration of the first stage was 4.10\u00a0\u00b1\u00a05.49\u00a0hours in the hyoscine and 5.29\u00a0\u00b1\u00a06.48\u00a0hours in the control group (<jats:italic>P<\/jats:italic>=0.03). Duration of the second and third stages was, respectively, 0.52\u00a0\u00b1\u00a00.53 and 0.14\u00a0\u00b1\u00a00.25\u00a0hours in the hyoscine, and 0.59\u00a0\u00b1\u00a01.08 and 0.12\u00a0\u00b1\u00a00.15\u00a0hours in the control group. No adverse effects were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Administration of oral hyoscine in an outpatient setting was found to ripen the cervix with no clinically significant adverse drug reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Iranian Registry of Clinical Trials (IRCT20180819040830N1)<\/jats:title><\/jats:sec>","DOI":"10.1002\/ijgo.13089","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T05:07:02Z","timestamp":1576645622000},"page":"335-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and safety of oral hyoscine used for outpatient cervical ripening among primiparous women with term pregnancy"],"prefix":"10.1002","volume":"150","author":[{"given":"Zahra","family":"Naeiji","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Shahid Beheshti University of Medical Science (SBUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narjes","family":"Naghshvarian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shahid Beheshti University of Medical Science (SBUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Mirzamoradi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shahid Beheshti University of Medical Science (SBUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sotudeh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shahid Beheshti University of Medical Science (SBUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atefeh","family":"Moridi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shahid Beheshti University of Medical Science (SBUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2017.08.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90376-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90279-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198303000-00013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2005.00359.x"},{"key":"e_1_2_7_7_1","unstructured":"Drug Information: Buscopan\u00ae.Ingelheim Germany:Boehringer Ingelheim Limited; 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