{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:26:53Z","timestamp":1778218013899,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the accuracy of a semi\u2010quantitative interleukin\u20106 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106) vaginal secretion rapid test (Chorioquick) for detecting chorioamnionitis in women with premature rupture of membranes (<jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study in five tertiary hospitals in Nigeria involved women with confirmed <jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content> at term and preterm <jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content> with or without suspected chorioamnionitis from August 1, 2017, to October 31, 2018. Cervicovaginal fluid samples were tested for chorioamnionitis using the Chorioquick test. Samples were repeated at decision to deliver. The test was considered positive if at least the indicator \u2018<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 low\u2019 of the three Chorioquick biomarkers (low, medium, high) was positive, or negative if none of the biomarkers were positive. Chorioamnionitis was histologically confirmed post\u2010delivery using three tissue samples. Primary outcome measures were sensitivity, specificity, and accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 73 women, on histological confirmation, 39 were true positive and 29 were true negative (for chorioamnionitis) to the Chorioquick test at repeat assessment. Overall, the Chorioquick test had a sensitivity of 97.5% (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 85.3\u201399.9), specificity 87.9% (70.9\u201396.0), and accuracy 93.2% (79.5\u201399.1). Sub\u2010group analysis of women &lt;37\u00a0weeks of pregnancy showed a sensitivity of 100.0% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 83.4\u2013100.0), specificity of 91.3% (70.5\u201398.5), and accuracy of 95.8% (82.5\u201399.5). Triple positive samples were 100.0% specific in all gestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chorioquick showed favorable utility for detecting chorioamnionitis in <jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content> and could be a reliable, non\u2010invasive rapid tool in a real\u2010world clinical setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13095","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T07:35:17Z","timestamp":1578382517000},"page":"98-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic value of Chorioquick for detecting chorioamnionitis in women with premature rupture of membranes"],"prefix":"10.1002","volume":"149","author":[{"given":"George U.","family":"Eleje","sequence":"first","affiliation":[{"name":"Effective Care Research Unit Department of Obstetrics and Gynecology Nnamdi Azikiwe University  Nnewi Nigeria"},{"name":"Department of Obstetrics and Gynecology Nnamdi Azikiwe University Teaching Hospital  Nnewi Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelius O.","family":"Ukah","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology and Forensic Medicine Nnamdi Azikiwe University Teaching Hospital  Nnewi Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igwebuike V.","family":"Onyiaorah","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology and Forensic Medicine Nnamdi Azikiwe University Teaching Hospital  Nnewi Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Euzebus C.","family":"Ezugwu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine University of Nigeria Enugu Campus  Enugu Nigeria"},{"name":"Department of Obstetrics and Gynecology University of Nigeria Teaching Hospital  Enugu Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel O.","family":"Ugwu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine University of Nigeria Enugu Campus  Enugu Nigeria"},{"name":"Department of Obstetrics and Gynecology University of Nigeria Teaching Hospital  Enugu Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel R.","family":"Ohayi","sequence":"additional","affiliation":[{"name":"Department of Histopathology Enugu State University of Science and Technology (ESUT) Teaching Hospital  Enugu Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia I.","family":"Eleje","sequence":"additional","affiliation":[{"name":"Measurement, Evaluation and Research Unit Department of Educational Foundations Nnamdi Azikiwe University  Awka Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard O.","family":"Egeonu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nnamdi Azikiwe University Teaching Hospital  Nnewi Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ifeanyichukwu U.","family":"Ezebialu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Chukwuemeka Odumegwu Ojukwu University Teaching Hospital  Awka Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chukwudi C.","family":"Obiora","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Enugu State University of Science and Technology (ESUT) Teaching Hospital  Enugu Nigeria"},{"name":"Department of Obstetrics and Gynecology Enugu State University of Science and Technology (ESUT) College of Medicine  Enugu Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph T.","family":"Enebe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Enugu State University of Science and Technology (ESUT) Teaching Hospital  Enugu Nigeria"},{"name":"Department of Obstetrics and Gynecology Enugu State University of Science and Technology (ESUT) College of Medicine  Enugu Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard O.","family":"Ajah","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine University of Nigeria Enugu Campus  Enugu Nigeria"},{"name":"Department of Obstetrics and Gynecology University of Nigeria Teaching Hospital  Enugu Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chigozie G.","family":"Okafor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nnamdi Azikiwe University Teaching Hospital  Nnewi Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chukwuemeka C.","family":"Okoro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nnamdi Azikiwe University Teaching Hospital  Nnewi Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augustine O.","family":"Asogwa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Nigeria Teaching Hospital  Enugu Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris K.","family":"Ogbuokiri","sequence":"additional","affiliation":[{"name":"Department of Anatomy Nnamdi Azikiwe University  Awka Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph I.","family":"Ikechebelu","sequence":"additional","affiliation":[{"name":"Effective Care Research Unit Department of Obstetrics and Gynecology Nnamdi Azikiwe University  Nnewi Nigeria"},{"name":"Department of Obstetrics and Gynecology Nnamdi Azikiwe University Teaching Hospital  Nnewi Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahizechukwu C.","family":"Eke","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Department of Gynecology and Obstetrics Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1006621"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2016.1219992"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173312"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001246"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1330407"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1053862"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2019.03.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.03.031"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208302"},{"key":"e_1_2_8_11_1","first-page":"219","article-title":"Early and late markers for the detection of early\u2010onset neonatal sepsis","volume":"55","author":"Bender L","year":"2008","journal-title":"Dan Med Bull"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.207"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)01146-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.908179"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.07.015"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e3283374ac8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.829814"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2016-0204"},{"key":"e_1_2_8_19_1","first-page":"71","article-title":"Diagnosis of intra\u2010amniotic infection","volume":"1","author":"Gibbs RS","year":"1977","journal-title":"Semin Perinatol"},{"issue":"3","key":"e_1_2_8_20_1","first-page":"383","article-title":"The prevalence and distribution of acute placental inflammation in uncomplicated term pregnancies","volume":"73","author":"Salafia CM","year":"1989","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1279600"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.01.013"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12073"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13573"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.09.017"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2016.57.2.461"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1815325"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijgo.13095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.13095","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T16:40:18Z","timestamp":1693154418000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.13095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,23]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/ijgo.13095"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.13095","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,23]]},"assertion":[{"value":"2019-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}