{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:46:00Z","timestamp":1792683960535,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Uterine leiomyomas are one of the most common and yet understudied diseases in women. These tumors, commonly known as fibroids, affect women mainly during their reproductive years and are diagnosed in up to 70% of white women and more than 80% of women of African ancestry during their lifetime. This disease has a profound impact on health care delivery and costs worldwide. Though most women with fibroids are asymptomatic, approximately 30% of them will present with severe symptoms which can include abnormal uterine bleeding, anemia, pelvic pain and pressure, back pain, urinary frequency, constipation, or infertility, and will require intervention. Furthermore, fibroids have been associated with poor obstetrical outcomes. The current options for symptomatic fibroid treatment include expectant, medical, and surgical management, and interventional radiology procedures. This article reviews the recent progress and available management strategies for uterine fibroids and highlights areas where further research is needed to find new therapeutic targets and better personalize treatments.<\/jats:p>","DOI":"10.1002\/ijgo.13102","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T05:57:06Z","timestamp":1579586226000},"page":"3-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":581,"title":["Epidemiology and management of uterine fibroids"],"prefix":"10.1002","volume":"149","author":[{"given":"Emma","family":"Giuliani","sequence":"first","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawsan","family":"As\u2010Sanie","sequence":"additional","affiliation":[{"name":"Division of Gynecology Department of Obstetrics and Gynecology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica E.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1209993"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1411029"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2005.12.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.02.017"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14640"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.99"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.12.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.03.019"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.09.027"},{"key":"e_1_2_7_11_1","first-page":"3249","article-title":"Environmental exposure and risk of uterine leiomyoma: An epidemiologic survey","volume":"17","author":"Shen Y","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt058"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu048"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002785"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.12.037"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2014.12.016"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2010.11.011"},{"issue":"2","key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/AOG.0b013e318183fbab","article-title":"ACOG practice bulletin. Alternatives to hysterectomy in the management of leiomyomas","volume":"112","author":"American College of Obstetricians and Gynecologists","year":"2008","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw023"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2018.61.2.192"},{"issue":"1","key":"e_1_2_7_21_1","first-page":"CD000400","article-title":"Non\u2010steroidal anti\u2010inflammatory drugs for heavy menstrual bleeding","author":"Lethaby A","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181f20177"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369390"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2014.05.002"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103182"},{"issue":"4","key":"e_1_2_7_26_1","first-page":"CD010770","article-title":"Selective progesterone receptor modulators (SPRMs) for uterine fibroids","author":"Murji A","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"e_1_2_7_27_1","first-page":"CD000547","article-title":"Pre\u2010operative GnRH analogue therapy before hysterectomy or myomectomy for uterine fibroids","author":"Lethaby A","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.05.006"},{"issue":"4","key":"e_1_2_7_29_1","first-page":"CD009747","article-title":"Daily iron supplementation for improving anaemia, iron status and health in menstruating women","author":"Low MSY","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"e_1_2_7_30_1","first-page":"CD009505","article-title":"Aromatase inhibitors for uterine fibroids","author":"Song H","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2327"},{"issue":"12","key":"e_1_2_7_32_1","first-page":"CD005073","article-title":"Uterine artery embolization for symptomatic uterine fibroids","author":"Gupta JK","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.06.051"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13669-016-0183-x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.11.033"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13519"},{"issue":"10","key":"e_1_2_7_37_1","first-page":"CD004638","article-title":"Minimally invasive surgical techniques versus open myomectomy for uterine fibroids","author":"Bhave Chittawar P","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.2196\/ijmr.3160"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.4293\/JSLS.2017.00041"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2017.10.003"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.05.004"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijgo.13102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.13102","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T12:41:23Z","timestamp":1693140083000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.13102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,17]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/ijgo.13102"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.13102","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,17]]},"assertion":[{"value":"2019-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}