{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:39:30Z","timestamp":1788381570580,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare maternal and perinatal outcomes between twin and single preterm births (<jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>) and associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional multicenter study was conducted in Brazil with 4046 <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>s from April 2011 to July 2012. Causes of <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>, use of tocolytics, corticosteroids, and antibiotics in twin and single pregnancies, and factors possibly associated with twinning were evaluated using \u03c7<jats:sup>2<\/jats:sup> tests. Maternal and perinatal outcomes were assessed with prevalence ratios (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The main cause of <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> in twin pregnancy was spontaneous onset of preterm labor. Tocolytics were more frequently used in twins (26.9% vs 20.2%). Factors associated with <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> in twins were: maternal age &gt;25\u00a0years (62.3% vs 53.4%); interpregnancy interval &gt;3\u00a0years (39.0% vs 33.4%); no history of <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> (87.4% vs 79.6%); no previous maternal conditions (78.0% vs 73.3%); no alcohol abuse (88.5% vs 84.3%); no drug addiction (97.5% vs 94.5%); and &gt;6 prenatal visits (46.5% vs 37.6%). Twin pregnancies run a 46% higher risk of cesarean delivery, while first and second twins face a 20% higher risk of low birth weight. Twin pregnancies run increased risks for admission to the <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content>, cerebral hemorrhage, necrotizing enterocolitis, and any adverse perinatal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preterm twin birth is associated with low birth weight and worse neonatal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13107","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T19:02:55Z","timestamp":1580756575000},"page":"184-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Maternal and perinatal outcomes and factors associated with twin pregnancies among preterm births: Evidence from the Brazilian Multicenter Study on Preterm Birth (<scp>EMIP<\/scp>)"],"prefix":"10.1002","volume":"149","author":[{"given":"Danielly S.","family":"Santana","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Campinas University School of Medicine  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose G.","family":"Cecatti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campinas University School of Medicine  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda G.","family":"Surita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campinas University School of Medicine  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo P.","family":"Tedesco","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jundiai Medical School  Jundia\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Renato","family":"Passini","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campinas University School of Medicine  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato T.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campinas University School of Medicine  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliane J.","family":"Lajos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campinas University School of Medicine  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabata Z.","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campinas University School of Medicine  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo L.","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campinas University School of Medicine  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M.","family":"Rehder","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campinas University School of Medicine  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria H.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jundiai Medical School  Jundia\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Brazilian Multicenter Study on Preterm Birth (EMIP) study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.10.865"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.02.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00345.x"},{"key":"e_1_2_8_6_1","unstructured":"National Collaborating Centre for Women's and Children's Health (UK).Multiple Pregnancy: The Management of Twin and Triplet Pregnancies in the Antenatal Period. 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