{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:28:15Z","timestamp":1783351695414,"version":"3.54.6"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2020,5]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To describe maternal and perinatal outcomes for women with chronic hypertension, comparing those with superimposed pre\u2010eclampsia (SPE<\/jats:styled-content>) with those without pre\u2010eclampsia (NPE<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>In a retrospective cohort study in a tertiary hospital in Brazil, the records of women with chronic hypertension were reviewed between January 1, 2012, and May 31, 2017, in order to compare maternal and perinatal outcomes among those with and without SPE<\/jats:styled-content>. Poisson regression was performed to investigate factors independently associated with severe pre\u2010eclampsia.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 385 women with chronic hypertension included in the study, 167 were in the SPE<\/jats:styled-content> group and 218 in the NPE<\/jats:styled-content> group. The majority were white, overweight (body mass index \u226530\u00a0kg\/m2<\/jats:sup>), with mean age around 31\u00a0years. Adverse neonatal outcomes were significantly more prevalent among women with SPE<\/jats:styled-content>, including small for gestational age (SPE<\/jats:styled-content> 17.46% vs NPE<\/jats:styled-content> 9.63%, P<\/jats:italic>=0.01), low birth weight (SPE<\/jats:styled-content> 2577\u00a0g\u00a0\u00b1\u00a0938 vs NPE<\/jats:styled-content> 3128\u00a0g\u00a0\u00b1\u00a0723, P<\/jats:italic>=0.003), neonatal intensive care unit admission (SPE<\/jats:styled-content> 44.91% vs NPE<\/jats:styled-content> 18.34%, P<\/jats:italic>=0.08), and incidence of cesarean delivery (SPE<\/jats:styled-content> 79.64% vs NPE<\/jats:styled-content> 62.38%, P<\/jats:italic>=0.003). Fetal growth restriction (PR<\/jats:styled-content> [prevalence ratio] 2.62, 95% confidence interval [CI<\/jats:styled-content>] 1.39\u20134.94) and previous pre\u2010eclampsia (PR<\/jats:styled-content> 1.96, 95% CI<\/jats:styled-content> 1.17\u20133.28) were associated with severe pre\u2010eclampsia.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>SPE<\/jats:styled-content> is associated with prematurity and higher rates of admission to neonatal intensive care unit. Fetal growth restriction and previous pre\u2010eclampsia are factors associated with severe complications of pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13114","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T04:18:19Z","timestamp":1581308299000},"page":"148-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Maternal and perinatal outcomes related to superimposed pre\u2010eclampsia in a Brazilian cohort of women with chronic hypertension"],"prefix":"10.1002","volume":"149","author":[{"given":"Laura","family":"Casagrande","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela P.","family":"Rezende","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Campinas Campinas 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