{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:29:18Z","timestamp":1791379758177,"version":"4.3.3"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2020,5]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>To assess the efficacy of self\u2010collected vaginal samples compared with physician\u2010collected cervical samples for the detection of HPVDNA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A hospital\u2010based cross\u2010sectional study was carried out among patients with newly diagnosed cervical cancer attending the Gynecologic Oncology Division, Department of Obstetrics and Gynecology and Radiation Oncology Department at Government Medical College, Kozhikode, Kerala between March 2017 and April 2019. Consenting patients collected their vaginal samples, followed by cervical sample collection by the clinician. The paired samples were transported at 4\u20138 \u00b0C to the laboratory. Amplification of LCR<\/jats:styled-content>\/E6\/E7 regions of the HPV<\/jats:styled-content> genome was done by polymerase chain reaction (PCR<\/jats:styled-content>). The agreement level between paired samples was assessed by the Kappa index.<\/jats:p><\/jats:sec>Results<\/jats:title>Among the 114 cervical cancer patients enrolled in the present cross\u2010sectional study, the prevalence of HPV DNA<\/jats:styled-content> was 78.1% (95% confidence interval [CI<\/jats:styled-content>] 69.2%\u201385%) in cervical samples and 77.2% in vaginal samples (95% CI<\/jats:styled-content> 68.7%\u201383.9%). The overall agreement between the two sampling methods was 93.9% and the kappa value was 0.82 (P<\/jats:italic><0.001). The sensitivity of HPV<\/jats:styled-content> detection using vaginal samples was 98.9% (95% CI<\/jats:styled-content> 93.9%\u201399.8%) and the specificity was 100% (95% CI<\/jats:styled-content> 86.7%\u2013100%) with cervical sampling as the gold standard. By Kappa index, an almost perfect agreement for HPV DNA<\/jats:styled-content> detection between self\u2010collected and physician\u2010collected samples was observed.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Self\u2010collection of vaginal samples ensures equity of cervical cancer screening in low\u2010income countries such as India.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13116","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T05:03:35Z","timestamp":1581311015000},"page":"219-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnostic accuracy of self\u2010collected vaginal samples for HPV DNA<\/scp> detection in women from South India"],"prefix":"10.1002","volume":"149","author":[{"given":"Santhosh","family":"Kuriakose","sequence":"first","affiliation":[{"name":"Gynecologic Oncology Division Department of Obstetrics and Gynecology Government Medical College Kozhikode Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasidharanpillai","family":"Sabeena","sequence":"additional","affiliation":[{"name":"Manipal Institute of Virology Manipal Academy of Higher Education Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damodaran","family":"Binesh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Government Medical College Kozhikode Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jazeel","family":"Abdulmajeed","sequence":"additional","affiliation":[{"name":"Manipal Institute of Virology Manipal Academy of Higher Education Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaraja","family":"Ravishankar","sequence":"additional","affiliation":[{"name":"Department of Data Science Manipal Academy of Higher Education Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrutha","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Division Department of Obstetrics and Gynecology Government Medical College Kozhikode Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindu","family":"Vijaykumar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Government Medical College Kozhikode Kozhikode Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurul","family":"Ameen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Government Medical College Kozhikode Kozhikode Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"BruniL AlberoG SerranoB et\u00a0al.;ICO\/IARC Information Centre on HPV and Cancer (HPV Information Centre).Human Papillomavirus and Related Diseases in India. Summary Report 17 June2019.https\u200b:\/\/hpvce\u200bntre.net\/stati\u200bstics\/\u200brepor\u200bts\/IND.pdf. Accessed July 15 2019."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.6.3641"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2012.23.3.141"},{"key":"e_1_2_8_5_1","unstructured":"ASCO Issues Global Recommendations to Increase Cervical Cancer Screening. [ASCO website].2016.https\u200b:\/\/www.asco.org\/about-asco\/press-cente\u200br\/news-relea\u200bses\/asco-issues-global-recom\u200bmenda\u200btions-incre\u200base-cervi\u200bcal-cancer. 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