{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T15:15:40Z","timestamp":1770995740674,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare accuracy between Premaquick (combined test for native insulin\u2010like growth factor binding protein\u20101 (<jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101), total <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101, and interleukin\u20106) and fetal fibronectin (Ffn) in predicting preterm delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective study among women at 28\u201336<jats:sup>+6<\/jats:sup> gestational weeks with threatened preterm labor attending Federal Medical Center, Owerri, Nigeria, from August 2017 to February 2019. Cervico\u2010vaginal fluids were collected and tested by Premaquick and Ffn tests. The women were followed for 14\u00a0days. Sensitivity, specificity, and negative (<jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content>) and positive (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>) predictive value for delivery were compared between the tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 213 women assessed for eligibility, 183 were enrolled and 175 completed the study. The sensitivity, specificity, <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> NPV<\/jats:styled-content>, and accuracy of the Premaquick versus Ffn tests were, respectively, 96.3% versus 51.9%, 97.6% versus 98.4%, 89.7% versus 87.5%, 99.2% versus 90.3% and 97.3% versus 90.0% for preterm delivery within 14\u00a0days. Ffn had higher specificity (98.5% vs 97.8%; <jats:italic>P<\/jats:italic>&gt;0.99), but Premaquick had higher <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> (92.7% vs 90.9%; <jats:italic>P<\/jats:italic>&gt;0.99).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both tests seem to have high utility in predicting preterm delivery, but Premaquick showed higher accuracy in terms of sensitivity and <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>. Premaquick might be a feasible alternative to Ffn for predicting preterm delivery among symptomatic women in a low\u2010income setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13128","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T04:41:22Z","timestamp":1582519282000},"page":"171-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Combined insulin\u2010like growth factor binding protein\u20101\/interleukin\u20106 (Premaquick) versus fetal fibronectin for predicting preterm delivery among women with preterm contractions"],"prefix":"10.1002","volume":"149","author":[{"given":"Amarachukwu C.","family":"Asiegbu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Federal Medical Centre  Owerri Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George U.","family":"Eleje","sequence":"additional","affiliation":[{"name":"Effective care Research Unit Department of Obstetrics and Gynaecology Nnamdi Azikiwe University  Awka Nigeria"},{"name":"Department of Obstetrics and Gynaecology Nnamdi Azikiwe University Teaching Hospital  Nnewi Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel M.","family":"Ibeneme","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Federal Medical Centre  Owerri Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onyema A.","family":"Onyegbule","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Federal Medical Centre  Owerri Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo C.","family":"Chukwu","sequence":"additional","affiliation":[{"name":"College of Medicine Chukwuemeka Odumegwu Ojukwu University  Awka 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