{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T04:33:16Z","timestamp":1752985996287},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of low\u2010dose aspirin, which was administered at or before the 16th week of pregnancy due to maternal characteristics and history of a pre\u2010existing medical condition, on prevention of pre\u2010eclampsia, and on the birth of a small\u2010for\u2010gestational\u2010age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) neonate without pre\u2010eclampsia in nulliparas in primary settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a case\u2013control study using population\u2010based data on 47\u00a0271 nulliparas with a singleton pregnancy who delivered in Slovenia from 2013 to 2017. The treated group received low\u2010dose aspirin. For the untreated group, propensity score matching was used to perform a 1:1 matching. In the matched sample, we calculated the odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) with a 95% confidence interval (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) with a two\u2010way test for pre\u2010eclampsia, as well as <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the treated group (n=584), the odds for an <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonate were significantly increased by 42.7% (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.427, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.001\u20132.034). However, we found no significant effect on the odds for pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.308, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.847\u20132.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In anticipation of more substantial population\u2010based data studies, in the Slovenian population, preventive treatment with low\u2010dose aspirin due to maternal characteristics and history of a pre\u2010existing medical condition is not beneficial for the prevention of pre\u2010eclampsia and can harm fetal growth.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13133","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T15:36:32Z","timestamp":1583163392000},"page":"333-338","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of current guidelines on prevention of pre\u2010eclampsia with low\u2010dose aspirin in primary settings: A population\u2010based case\u2013control study"],"prefix":"10.1002","volume":"149","author":[{"given":"Tanja","family":"Premru\u2010Srsen","sequence":"first","affiliation":[{"name":"Division of Obstetrics and Gynecology Department of Perinatology University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Medical Faculty University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zorana","family":"Kocic","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology Department of Perinatology University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Verdenik","sequence":"additional","affiliation":[{"name":"Research Unit, Division of Obstetrics and Gynecology University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"e323","article-title":"Global causes of maternal death: A WHO systematic analysis","volume":"2","author":"Say L","year":"2014","journal-title":"Lancet"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.01.004"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Gestational hypertension and preeclampsia","volume":"95","author":"American College of Obstetricians and Gynecologists Bulletin","year":"2019","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_5_1","unstructured":"World Health Organization.Prevention and Treatment of Pre\u2010Eclampsia and Eclampsia. Published2011. doi:WHO\/RHR\/11.30 Accessed April 3 2019."},{"key":"e_1_2_8_6_1","unstructured":"\u2010HendersonJT WhitlockEP O'ConnerE SengerCA ThompsonJH RowlandMG.Low\u2010Dose Aspirin for the Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force. Evidence Synthesis No. 112. AHRQ Publication No. 14\u201005207\u2010EF\u20101.Rockville MD:Agency for Healthcare. Published2014.http:\/\/www.ncbi.nlm.nih.gov\/books\/\u200bNBK19\u200b6400\/. 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